Description
ACTG2 Antibody (PACO33260)
The ACTG2 Polyclonal Antibody (PACO33260) is a valuable tool for researching the ACTG2 gene, which encodes for a protein involved in smooth muscle contraction. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ACTG2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in muscle biology, gastrointestinal disorders, and smooth muscle-related diseases.ACTG2, a member of the actin protein family, plays a crucial role in regulating the contractile function of smooth muscle cells. Dysregulation of ACTG2 expression or function has been associated with various pathological conditions, including gastrointestinal motility disorders and smooth muscle-related diseases such as Hirschsprung's disease.
Understanding the molecular mechanisms governing ACTG2 activity is essential for developing targeted therapies aimed at modulating smooth muscle contractility and addressing related disorders. In conclusion, the ACTG2 Polyclonal Antibody (PACO33260) is a reliable reagent for investigating the function and regulation of the ACTG2 gene in various research applications. Its specificity and sensitivity make it a valuable tool for researchers studying smooth muscle biology and related diseases.
| Antibody Name: | ACTG2 Antibody (PACO33260) |
| Antibody SKU: | PACO33260 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Actin, gamma-enteric smooth muscle protein (181-376AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: ACTG2 antibody at 3µg/ml + CEM whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 42, 38 kDa Observed band size: 42 kDa . |
 | Immunohistochemistry of paraffin-embedded human colon tissue using PACO33260 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO33260 at dilution of 1:100. |
| Background: | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| Synonyms: | Actin, gamma-enteric smooth muscle (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form], ACTG2, ACTA3 ACTL3 ACTSG |
| UniProt Protein Function: | ACTG2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family. |
| UniProt Protein Details: | Protein type:Contractile; Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: cytoplasm; cytosol; extracellular space; filopodium; lamellipodium Biological Process: muscle contraction Disease: Visceral Myopathy |
| NCBI Summary: | Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010] |
| UniProt Code: | P63267 |
| NCBI GenInfo Identifier: | 54036679 |
| NCBI Gene ID: | 72 |
| NCBI Accession: | P63267.1 |
| UniProt Secondary Accession: | P63267,P12718, Q504R1, Q6FI22, B2R7E7, B4E315, D6W5H8 E9PG30, |
| UniProt Related Accession: | P63267 |
| Molecular Weight: | 37,083 Da |
| NCBI Full Name: | Actin, gamma-enteric smooth muscle |
| NCBI Synonym Full Names: | actin, gamma 2, smooth muscle, enteric |
| NCBI Official Symbol: | ACTG2Â Â |
| NCBI Official Synonym Symbols: | ACT; ACTE; VSCM; ACTA3; ACTL3; ACTSGÂ Â |
| NCBI Protein Information: | actin, gamma-enteric smooth muscle |
| UniProt Protein Name: | Actin, gamma-enteric smooth muscle |
| UniProt Synonym Protein Names: | Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin |
| Protein Family: | Actin |
| UniProt Gene Name: | ACTG2Â Â |
| UniProt Entry Name: | ACTH_HUMAN |
| Antibodies | ELISA Kits |
| ACTG2 Antibody (PACO06229) | Actin-gamma2 Colorimetric Cell-Based ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
