Description
Anti-Human CD119 (IFN-γ Rα Chain) In Vivo Antibody - Ultra Low Endotoxin
Introducing the Anti-Human CD119 (IFN-γ R1 chain) In Vivo Antibody - Ultra Low Endotoxin from Assay Genie, a highly specific monoclonal antibody tailored for in vivo applications. This antibody targets the CD119 protein, which is a critical component of the interferon-gamma receptor, making it ideal for research in immunology and related fields. With a mouse IgG isotype, it ensures exceptional purity and ultra-low endotoxin levels (<0.02 EU/mg), perfect for ELISA, flow cytometry, immunohistochemistry, and other assays. Available in various sizes, it is formulated in phosphate-buffered saline for optimal stability and efficacy.
Enhance your research with this reliable and versatile antibody. CD119 is a receptor chain for interferon-gamma (IFN-γ), playing a key role in mediating the immune response to pathogens. It is found on the surface of various immune cells, including macrophages, dendritic cells, and natural killer cells. This receptor is essential for the activation and regulation of immune responses, particularly in host defense mechanisms against infections and cancer.
| Product Name: | Anti-Human CD119 (IFN-γ R-α Chain) In Vivo Antibody - Ultra Low Endotoxin |
| Product Code: | IVMB0104 |
| Size: | `1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | GIR-208 |
| Protein: | IFN-gamma R-alpha |
| Product Type: | Monoclonal Antibody |
| Synonyms: | IFNGR1, IFN-gamma R, IFN-gamma R-alpha, IFN-α R1, CDw119 |
| Isotype: | Mouse IgG1 |
| Reactivity: | Human |
| Immunogen: | Human IFN-gamma R-alpha, Purified from human placenta |
| Applications: | FA, FC |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | <0.5 EU/mg as determined by the LAL method |
| Purity: | ≥98% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | FA, FC |
| Recommended Usage: | FC The suggested concentration for clone GIR-208 purified antibody for staining cells in flow cytometry is ≤ 0.5 µg per 106 in a volume of 100 µl or 100µl of whole blood. Titration of the reagent is recommended for optimal performance for each application. |
| Reactivity: | Human |
| Host Species: | Mouse |
| Specificity: | Clone GIR-208 recognizes an epitope on human IFN-gamma R-alpha. |
| Antigen Distribution: | The IFN-gamma receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes. |
| Immunogen: | Human IFN-gamma R-alpha, Purified from human placenta |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | <0.5 EU/mg as determined by the LAL method |
| Purity: | ≥98% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
IFNγ Rα, or IFNγ R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ Receptor consists of α and β chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription.
| Technical Datasheet: | View |
| Protein: | IFN-gamma R-alpha |
| Research Area: | Immunology |
| Mouse IgG1 Isotype Control [HKSP84] | |
|---|---|
| Clone | HKSP84 |
| Isotype | Mouse IgG1 |
| Endotoxin Level | Ultra Low Endotoxin |
| Mouse IgG1 Isotype Control [HKSP] | |
|---|---|
| Clone | HKSP |
| Isotype | Mouse IgG1 |
| Endotoxin Level | Ultra Low Endotoxin |
