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Anti-Human CD16 [3G8] - Purified Invivo Antibody (IVMB0261)

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SKU IVMB0261
Product Type In Vivo Monoclonal Antibody
Clone 3G8
Protein CD16
Isotype IgG1 k
Reactivity Baboon, Chimpanzee, Cynomolgus Monkey, Marmoset, Pigtailed Macaque, Rhesus Monkey, Squirrel Monkey, Human
Research Area Immunology, Innate Immunity
Host Species Mouse
Applications Blocking, CyTOF, FC, IHC FF, IP
Target / Synonyms::FcgammaRIII · Fc Gamma RIII
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Description

Product Name:Anti-Human CD16 (Clone 3G8) - Purified Invivo Antibody
Product Code:IVMB0261
Clone:3G8
Protein:CD16
Product Type:Monoclonal Antibody
Synonyms:FcgammaRIII, Fc Gamma RIII
Isotype:IgG1 k
Reactivity:Baboon, Chimpanzee, Cynomolgus Monkey, Marmoset, Pigtailed Macaque, Rhesus Monkey, Squirrel Monkey, Human
Applications:B, CyTOF®, FC, IHC FF, IP
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:B, CyTOF®, FC, IHC FF, IP
Reactivity:Baboon, Chimpanzee, Cynomolgus Monkey, Marmoset, Pigtailed Macaque, Rhesus Monkey, Squirrel Monkey, Human
Host Species:Mouse
Specificity:Clone 3G8 recognizes an epitope on human CD16. This clone also cross-reacts with non-human primate CD16.
Antigen Distribution:CD16 is expressed on NK cells, activated monocytes, macrophages, neutrophils, and placental trophoblasts.
Immunogen:Human PMN cells
Concentration:0.5 mg/ml
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:This purified antibody is stable when stored at 2-8°C. Do not freeze.

CD16 antibody, 3G8, recognizes human CD16, also known as low-affinity IgG receptor III (FcgammaRIII). There are two distinct forms of CD16, CD16a (FcgammaRIIIa) and CD16b (FcgammaRIIIb). CD16a is a 50-65 kDa heterooligomeric polypeptide-anchored transmembrane protein expressed by NK cells, macrophages, and subsets of monocytes1. CD16b is a 48 kDa monomeric glycosylphosphatidylinositol (GPI)-anchored protein expressed on neutrophils1. Upon binding to the Fc portion of IgG or IgG-antigen complex, both CD16 isoforms induce signaling cascades resulting in multiple functions, including phagocytosis, cytokine release, proliferation, degranulation, and antibody dependent cell-mediated cytotoxicity (ADCC)2.

Protein:CD16
Function:Low affinity IgG Fc receptor, phagocytosis, ADCC
Ligand/Receptor:Aggregated IgG, IgG-antigen complex
Research Area:Immunology, Innate Immunity
Shipping:2-8°C
NCBI Gene Bank ID:2214
UniProt:CD16

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