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Anti-Human CD16 [3G8] - Purified Invivo Antibody (IVMB0261)

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SKU IVMB0261
Product Type In Vivo Monoclonal Antibody
Clone 3G8
Protein CD16
Isotype IgG1 k
Reactivity Baboon
Reactivity Chimpanzee
Reactivity Cynomolgus Monkey
Reactivity Marmoset
Reactivity Pigtailed Macaque
Reactivity Rhesus Monkey
Reactivity Squirrel Monkey
Reactivity Human
Synonyms FcgammaRIII
Synonyms Fc Gamma RIII
Research Area Immunology
Research Area Innate Immunity
Host Species Mouse
Applications Blocking
Applications CyTOF
Applications FC
Applications IHC FF
Applications IP
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Description

Product Name:Anti-Human CD16 (Clone 3G8) - Purified Invivo Antibody
Product Code:IVMB0261
Clone:3G8
Protein:CD16
Product Type:Monoclonal Antibody
Synonyms:FcgammaRIII, Fc Gamma RIII
Isotype:IgG1 k
Reactivity:Baboon, Chimpanzee, Cynomolgus Monkey, Marmoset, Pigtailed Macaque, Rhesus Monkey, Squirrel Monkey, Human
Applications:B, CyTOF®, FC, IHC FF, IP
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:B, CyTOF®, FC, IHC FF, IP
Reactivity:Baboon, Chimpanzee, Cynomolgus Monkey, Marmoset, Pigtailed Macaque, Rhesus Monkey, Squirrel Monkey, Human
Host Species:Mouse
Specificity:Clone 3G8 recognizes an epitope on human CD16. This clone also cross-reacts with non-human primate CD16.
Antigen Distribution:CD16 is expressed on NK cells, activated monocytes, macrophages, neutrophils, and placental trophoblasts.
Immunogen:Human PMN cells
Concentration:0.5 mg/ml
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:This purified antibody is stable when stored at 2-8°C. Do not freeze.

CD16 antibody, 3G8, recognizes human CD16, also known as low-affinity IgG receptor III (FcgammaRIII). There are two distinct forms of CD16, CD16a (FcgammaRIIIa) and CD16b (FcgammaRIIIb). CD16a is a 50-65 kDa heterooligomeric polypeptide-anchored transmembrane protein expressed by NK cells, macrophages, and subsets of monocytes1. CD16b is a 48 kDa monomeric glycosylphosphatidylinositol (GPI)-anchored protein expressed on neutrophils1. Upon binding to the Fc portion of IgG or IgG-antigen complex, both CD16 isoforms induce signaling cascades resulting in multiple functions, including phagocytosis, cytokine release, proliferation, degranulation, and antibody dependent cell-mediated cytotoxicity (ADCC)2.

Protein:CD16
Function:Low affinity IgG Fc receptor, phagocytosis, ADCC
Ligand/Receptor:Aggregated IgG, IgG-antigen complex
Research Area:Immunology, Innate Immunity
Shipping:2-8°C
NCBI Gene Bank ID:2214
UniProt:CD16

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