![Anti-Human CD38 [OKT10] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/1280x1280/products/214454/569465/anti-human-cd38-okt10-in-vivo-antibody-low-endotoxin__74367.1673496995.jpg?c=2?imbypass=on "Anti-Human CD38 [OKT10] In Vivo Antibody - Low Endotoxin")
Description
| Product Name: | Anti-Human CD38 [OKT10] In Vivo Antibody - Low Endotoxin |
| Product Code: | IVMB0119 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | OKT10 |
| Protein: | CD38 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | ADPRC1 |
| Isotype: | Mouse IgG1 |
| Reactivity: | Rhesus Monkey, Human |
| Applications: | FC |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | FC |
| Recommended Usage: | FC The suggested concentration for this OKT10 antibody for staining cells in flow cytometry is ≤ 1 µg per 106 in a volume of 100 µl or 100µl of whole blood. Titration of the reagent is recommended for optimal performance for each application. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. |
| Reactivity: | Rhesus Monkey, Human |
| Host Species: | Mouse |
| Specificity: | Clone OKT10 recognizes an epitope on human CD38. |
| Antigen Distribution: | CD38 is present on the surface of immune cells such as CD4+, CD8+, B lymphocytes, natural killer cells, mature lymphocytes, and mature lymphoplasmacytic cells. |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
CD38 is a 45kD type II transmembrane glycoprotein that plays a role in the regulation of intracellular Ca2+ by synthesizing and hydrolyzing an intracellular calcium ion mobilizing messenger. CD38 has both extracellular and intracellular functions as indicated by the release of soluble protein and the ability of membrane-bound protein to become internalized. The functional molecule is a dimer that contains the catalytic site in the central portion, and is involved in both extracellular and intracellular functions. CD38 plays a role in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a biomarker to measure the progress of a chronic lymphocytic leukemia in patients. Because CD38 is expressed on mature lymphocytes and lymphoplasmacytic cells, OKT10 can be used to study final B cell maturation. OKT10 reactivity with CD38 occurs in an inversely proportional relationship to the occurrence of Ia-like antigenic expression. Hence, these two antigens can be used as reciprocal complementary reactants for the study of mature B cell malignancies, such as CLL, multiple myeloma, and Waldenström malignancy.
| Technical Datasheet: | View |
| Protein: | CD38 |
| Ligand/Receptor: | CD31, hyaluronic acid |
| Research Area: | Cell Adhesion, Cell Biology, Immunology |
| Mouse IgG1 Isotype Control [HKSP] | |
|---|---|
| Clone | HKSP |
| Isotype | Mouse IgG1 |
| Endotoxin Level | Low Endotoxin |
| Mouse IgG1 Isotype Control [HKSP84] | |
|---|---|
| Clone | HKSP84 |
| Isotype | Mouse IgG1 |
| Endotoxin Level | Low Endotoxin |
![Anti-Human CD38 [OKT10] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/608x608/products/214454/569465/anti-human-cd38-okt10-in-vivo-antibody-low-endotoxin__74367.1673496995.jpg?c=2 "Anti-Human CD38 [OKT10] In Vivo Antibody - Low Endotoxin")
![Anti-Human CD38 [OKT10] In Vivo Antibody - Ultra Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/214455/569406/anti-human-cd38-okt10-in-vivo-antibody-ultra-low-endotoxin__05614.1673496772.jpg?c=2 "Anti-Human CD38 [OKT10] In Vivo Antibody - Ultra Low Endotoxin")
