Anti-Human Hepsin [2D5] In Vivo Antibody - Ultra Low Endotoxin
Introducing the Anti-Human Hepsin 2D5 In Vivo Antibody - Ultra Low Endotoxin from Assay Genie, a highly specific monoclonal antibody tailored for in vivo applications. This antibody targets the Hepsin protein, a critical component in various cellular processes, making it an excellent tool for research in oncology and related fields. With a mouse IgG1 isotype, it guarantees high purity and ultra-low endotoxin levels (<0.01 EU/µg), making it ideal for in vivo experiments, ensuring minimal inflammatory responses. This antibody's formulation in phosphate-buffered saline maintains its stability and efficacy across various applications, including immunohistochemistry, Western blotting, and other assays.
Available in multiple sizes, the Anti-Human Hepsin 2D5 In Vivo Antibody is engineered to support and enhance your cutting-edge research. Hepsin is a serine protease involved in cell growth and development, with significant implications in cancer progression and metastasis. Its overexpression has been linked to several carcinomas, making it a valuable target for therapeutic research and cancer diagnostics. Elevate your scientific investigations with this dependable and adaptable antibody.
Product Name:
Anti-Human Hepsin (Clone 2D5) In Vivo Antibody - Ultra Low Endotoxin
Product Code:
IVMB0359
Size:
1 mg, 5 mg, 25 mg, 50 mg, 100 mg
Clone:
2D5
Protein:
Hepsin
Product Type:
Monoclonal Antibody
Synonyms:
HPN, TMPRSS1, 2D5-1.9, 2D5.1.9
Isotype:
IgG2a
Reactivity:
Human
Applications:
ELISA, FC, In Vivo, WB
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Purity:
≥98% monomer by analytical SEC â‹… >95% by SDS Page
Product Preparation:
Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:
ELISA, FC, In Vivo, WB
Reactivity:
Human
Host Species:
Mouse
Specificity:
Clone 2D5 recognizes Human hepsin. It binds to a separate epitope than clone 3H10.1. These clones do not interfere with one another.
Antigen Distribution:
Hepsin is expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues.
Immunogen:
Human hepsin protein
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Purity:
≥98% monomer by analytical SEC â‹… >95% by SDS Page
Preparation:
Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Hepsin is a type II transmembrane serine protease (TTSP) expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues. The physiological function of hepsin is unclear, although, In vitro studies have shown that hepsin activates blood clotting factors VII, XII, and IX, pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF). The over-expression of hepsin has been implicated in several types of cancer, especially ovarian and prostate, which makes it an attractive diagnostic marker for cancers. Most notably, hepsin has been identified as one of the most highly induced genes in prostate cancer, and this over-expression is correlated with the cancer progression and metastasis. Furthermore anti-hepsin antibodies have been shown to inhibit the invasion of human prostate cancer cells.1
Protein:
Hepsin
Pathogen Testing:
To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Assay Genie's Purified Functional Antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
![Anti-Human Hepsin [3H10.1] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/214464/569460/anti-human-hepsin-3h10.1-in-vivo-antibody-low-endotoxin__22550.1673496990.jpg?c=2 "Anti-Human Hepsin [3H10.1] In Vivo Antibody - Low Endotoxin")
