Description
Anti-Mouse NK1.1 In Vivo Antibody - Ultra Low Endotoxin
Introducing the Anti-Mouse NK1.1 In Vivo Antibody - Ultra Low Endotoxin from Assay Genie, a highly specific monoclonal antibody designed for in vivo applications. This antibody targets the NK1.1 protein, which is essential in natural killer (NK) cell function, making it ideal for research in immunology and related fields.
With its mouse IgG2a isotype, it ensures high purity and ultra-low endotoxin levels (<0.01 EU/μg), perfect for experimental applications where endotoxin levels are critical. Available in various sizes, it is formulated in phosphate-buffered saline for stability and efficacy. Enhance your research with this reliable and versatile antibody. NK1.1, also known as NKRP1 or CD161, is a receptor found on the surface of NK cells, a subset of lymphocytes involved in the innate immune response. It plays a significant role in identifying and eliminating virally infected cells and tumors. This antibody is particularly valuable for studying NK cell-mediated cytotoxicity, immune regulation, and the broader innate immunity.
| Product Name: | Anti-Mouse NK1.1 In Vivo Antibody - Ultra Low Endotoxin |
| Product Code: | IVMB0101 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | PK136 |
| Protein: | NK1.1 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | Natural Killer Cells, KR-P1C, NKR-P1B, Ly-55, CD161b, CD161c |
| Isotype: | Mouse IgG2a κ |
| Reactivity: | Mouse |
| Immunogen: | NK-1+ cells from mouse spleen and bone marrow |
| Applications: | B, CyTOF®, Depletion, FC, IP, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | <0.5 EU/mg as determined by the LAL method |
| Purity: | ≥98% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | B, CyTOF®, Depletion, FC, IP, WB |
| Reactivity: | Mouse |
| Host Species: | Mouse |
| Specificity: | Clone PK136 recognizes mouse NK1.1. |
| Antigen Distribution: | NK-1.1 is encoded by the NKR-P1B/NKR-P1C gene and expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. |
| Immunogen: | NK-1+ cells from mouse spleen and bone marrow |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | <0.5 EU/mg as determined by the LAL method |
| Purity: | ≥98% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
NK1.1 is a type II membrane protein that is part of the C-type lectin superfamily. NK1.1 contains a transmembrane domain and a cytoplasmic domain that are characteristic of C-type lectins. The function of NK cells is to mediate cytotoxicity and to secrete cytokines after immune stimulation. NK1.1 has been correlated with lysis of tumor cells In vitro and rejection of bone marrow allografts In vivo. It is also involved in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 is commonly used as a mouse NK cell marker.
| Technical Datasheet: | View |
| Protein: | NK1.1 |
| Research Area: | Immunology, Innate Immunity |
| Mouse IgG2a Isotype Control | |
|---|---|
| Clone | C1.18.4 |
| Isotype | Mouse IgG2a kappa |
| Endotoxin Level | Ultra Low Endotoxin |
