The RAIDD/CRADD Monoclonal Antibody (CAB8663) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, produced in rabbits, shows strong reactivity with human samples and is validated for use in Western blot applications. By targeting the RAIDD/CRADD protein, this antibody enables detection and analysis in various cell types, making it a valuable tool for studies in cell biology, immunology, and cancer research.RAIDD/CRADD, also known as the CRADD protein or CASP2 and RIPK1 domain containing adaptor with death domain, is a key regulator of apoptotic cell death and immune signaling.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
RAIDD/CRADD Monoclonal Antibody
SKU:
CAB8663
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC1770
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
MRT34, RAIDD, RAIDD/CRADD
Positive Sample:
HT-29, 293T, K-562
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
23kDa
Observed MW:
23kDa
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
8738
RRID
AB_2863580
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using RAIDD/CRADD Rabbit mAb (CAB8663) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
