The Anti-VDR Antibody (CAB20840) offered by AssayGenie is a powerful tool for researchers studying the Vitamin D Receptor (VDR) protein. This polyclonal antibody is raised in rabbits and is highly specific to VDR in human samples, making it ideal for Western blot applications.The VDR protein plays a crucial role in regulating the effects of Vitamin D in the body, influencing processes such as calcium metabolism, cell growth, and immune function. Dysregulation of VDR has been implicated in various diseases, including cancer, autoimmune disorders, and osteoporosis.
By using the Anti-VDR Antibody, researchers can detect and analyze VDR expression in different cell types, providing valuable insights into the role of this protein in health and disease. This antibody is a valuable tool for studies in immunology, cancer research, and other fields where VDR signaling is of interest.Overall, the Anti-VDR Antibody from AssayGenie is a reliable and specific reagent that can help advance research into the functions of the Vitamin D Receptor and its implications for human health.
Product Name:
VDR Monoclonal Antibody
SKU:
CAB20840
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human VDR (NP_000367.1).
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Purification Method:
Affinity purification
Gene ID:
7421
Clone Number:
ARC51248
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using VDR antibody (CAB20840) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
