The Biotinylated Anti-B7-H3 Antibody (HDLA018) is a valuable tool for research into B7-H3, a member of the B7 family of immune checkpoint proteins. This antibody, produced using advanced biotinylation technology, specifically targets B7-H3 in human samples, making it an excellent choice for a variety of immunology and cancer research applications.B7-H3 is known for its role in regulating immune responses and promoting immune tolerance, making it a key player in the development of therapeutic strategies for cancer and other diseases. The Biotinylated Anti-B7-H3 Antibody allows for the specific detection and analysis of B7-H3 expression in various cell types, providing researchers with critical insights into its function and potential as a target for immunotherapy.
With its high specificity and sensitivity, this antibody is a valuable tool for studying the role of B7-H3 in immune modulation and its implications for disease progression. Its versatility in applications such as Western blotting and immunofluorescence makes it an essential component of any research project focused on understanding the complex interplay between the immune system and disease.
SKU:
HDLA018
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM53
Synonyms:
B7-H3, CD276, B7 homolog 3, B7H3
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
