The Biotinylated Anti-CD27 Antibody (HDLA020) is a high-quality reagent designed for the detection and analysis of CD27, a cell surface molecule involved in regulating immune responses. This antibody, produced and purified using advanced techniques, specifically binds to the CD27 protein with high affinity and specificity, making it an essential tool for immunology and cancer research studies.CD27, also known as Tumor Necrosis Factor Receptor Superfamily Member 7 (TNFRSF7), is crucial for the activation and differentiation of immune cells such as T cells and B cells. Its role in immune response modulation and cell signaling pathways makes it a valuable target for investigating diseases like cancer, infectious diseases, and autoimmune disorders.
With its ability to detect CD27 in various cell types and tissues, the Biotinylated Anti-CD27 Antibody (HDLA020) provides researchers with a reliable tool for studying the function and expression of CD27 in different biological contexts. Whether used in Western blotting, immunofluorescence, or flow cytometry experiments, this antibody ensures accurate and reproducible results, advancing our understanding of immune regulation and potential therapeutic targets.
SKU:
HDLA020
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM57
Synonyms:
CD27, TNFRSF7, S152, T14, Tp55
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
