Canine GM CSF Recombinant Protein (RPPB0360)
- SKU:
- RPPB0360
- Product Type:
- Recombinant Protein
- Species:
- Canine
- Uniprot:
- P48749
Description
| Product Name: | Canine GM CSF Recombinant Protein |
| Product Code: | RPPB0360 |
| Size: | 10µg |
| Species: | Canine |
| Target: | GM CSF |
| Synonyms: | CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, MGC131935, MGC138897. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | GMCSF was lyophilized after extensive dialysis against 1xPBS pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized GMCSF in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GMCSF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GMCSF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 96.0% as determined by1. Analysis by RP-HPLC.2. Analysis by SDS-PAGE. |
| Amino Acid Sequence: | APTRSPTLVT RPSQHVDAIQ EALSLLNNSN DVTAVMNKAV KVVSEVFDPEGPTCLETRLQ LYKEGLQGSL TSLKNPLTMM ANHYKQHCPP TPESPCATQNINFKSFKENL KDFLFNIPFD CWKPVKK |
| Biological Activity: | The ED50 as calculated by the dose-dependent stimulation of the proliferation of human TF1 erythroleukemic cells is typically 1-4 ng/ml. |
GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
GMCSF k9 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 128 amino acids and having a molecular mass of 14.2 kDa. GM-CSF is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P48749 |
| NCBI GenInfo Identifier: | 50979038 |
| NCBI Gene ID: | 403923 |
| NCBI Accession: | NP_001003245.1 |
| UniProt Secondary Accession: | P48749 |
| UniProt Related Accession: | P48749 |
| Molecular Weight: | 16,137 Da |
| NCBI Full Name: | granulocyte-macrophage colony-stimulating factor |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | CSF2�� |
| NCBI Official Synonym Symbols: | GM-CSF�� |
| NCBI Protein Information: | granulocyte-macrophage colony-stimulating factor |
| UniProt Protein Name: | Granulocyte-macrophage colony-stimulating factor |
| UniProt Synonym Protein Names: | Colony-stimulating factor; CSF |
| Protein Family: | Granulocyte-macrophage colony-stimulating factor |
| UniProt Gene Name: | CSF2�� |
| UniProt Entry Name: | CSF2_CANLF |
