Description
Caspase-9 Polyclonal Antibody (CAB21682)
The Caspase-9 Polyclonal Antibody offered by AssayGenie is a valuable tool for research involving caspase-9, a critical enzyme in the apoptotic pathway. This antibody is produced in rabbits and is highly specific for detecting caspase-9 in human samples, making it an essential tool for Western blot applications.Caspase-9 is a key player in the regulation of programmed cell death and is involved in various physiological and pathological processes, including development, cancer, and neurodegenerative diseases. By targeting caspase-9 with this antibody, researchers can gain valuable insights into its role in apoptosis and potentially develop targeted therapies for conditions characterized by dysregulated cell death.
Overall, the Caspase-9 Polyclonal Antibody from AssayGenie is a reliable reagent for investigating the function and regulation of caspase-9 in a wide range of research areas, including cancer biology, neurology, and developmental biology. Its high specificity and sensitivity make it a valuable asset for any laboratory studying apoptosis and cell death mechanisms.
| Product Name: | Caspase-9 Polyclonal Antibody |
| Product Code: | CAB21682 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, HepG2 |
| Cellular Location: | apoptosome, cytoplasm, cytosol, mitochondrion, nucleus |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 139-416 of Caspase-9 (NP_001220.2). |
| Sequence: | VGALE SLRGN ADLAY ILSME PCGHC LIINN VNFCR ESGLR TRTGS NIDCE KLRRR FSSLH FMVEV KGDLT AKKMV LALLE LAQQD HGALD CCVVV ILSHG CQASH LQFPG AVYGT DGCPV SVEKI VNIFN GTSCP SLGGK PKLFF IQACG GEQKD HGFEV ASTSP EDESP GSNPE PDATP FQEGL RTFDQ LDAIS SLPTP SDIFV SYSTF PGFVS WRDPK SGSWY VETLD DIFEQ WAHSE DLQSL LLRVA NAVSV KGIYK QMPGC FNFLR KKLFF KTS |
| Synonyms: | MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6 |
| Calculated MW: | 46kDa |
| Observed MW: | 45kDa |
