The CASQ2 Polyclonal Antibody (CAB16797) is a valuable tool for researchers studying CASQ2, a critical protein involved in muscle contraction and calcium regulation within the heart. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the CASQ2 protein, researchers can detect and analyze its expression in a variety of cell types, making it an essential component for studies in cardiology and muscle physiology.
CASQ2, also known as calsequestrin-2, plays a vital role in regulating calcium levels in the sarcoplasmic reticulum of cardiac muscle cells, crucial for proper muscle contraction and relaxation. Mutations in the CASQ2 gene have been associated with arrhythmias and other heart disorders, making it a target of interest for research into cardiovascular diseases. Understanding the function and expression of CASQ2 is essential for developing potential treatments and interventions for these conditions.
Product Name:
CASQ2 Rabbit Polyclonal Antibody
SKU:
CAB16797
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2).
The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
Purification Method:
Affinity purification
Gene ID:
845
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CASQ2 Rabbit pAb (CAB16797) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
