The CCR8 Polyclonal Antibody (CAB8048) is a valuable tool for researchers studying CCR8, a chemokine receptor that plays a key role in immune response regulation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CCR8 protein, this antibody allows for the detection and analysis of CCR8 expression in various cell types, making it a valuable resource for studies in immunology and inflammatory diseases.CCR8 is known for its involvement in directing immune cell migration and promoting inflammation in response to chemokine signals.
Its dysregulation has been implicated in various inflammatory conditions, making it a potential target for therapeutic interventions. Research on CCR8 function is essential for uncovering new insights into immune response mechanisms and developing targeted therapies for inflammatory disorders.Overall, the CCR8 Polyclonal Antibody is a reliable tool for researchers looking to investigate the role of CCR8 in immune regulation and inflammatory diseases. Its specificity and sensitivity make it a valuable asset for studies aimed at understanding the underlying mechanisms of immune response modulation.
Product Name:
CCR8 Rabbit Polyclonal Antibody
SKU:
CAB8048
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 296-355 of human CCR8 (NP_005192.1).
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
Purification Method:
Affinity purification
Gene ID:
1237
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CCR8 antibody (CAB8048) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
