The CDC42 Polyclonal Antibody (CAB15657) is specifically designed for research involving CDC42, a small GTPase protein involved in cellular signaling pathways and regulating cell morphology. This antibody, produced in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunofluorescence.CDC42 is a key player in the regulation of cell cycle progression, cell migration, and cytoskeletal reorganization. Dysregulation of CDC42 has been linked to cancer progression, neurodegenerative disorders, and cardiovascular diseases.
Studying the activity and expression of CDC42 using this antibody can provide valuable insights into the role of CDC42 in various cellular processes and diseases.With its high specificity and sensitivity, the CDC42 Polyclonal Antibody is an essential tool for researchers in cell biology, cancer biology, and neuroscience looking to investigate the functions of CDC42 and its potential as a therapeutic target. Its ability to detect and analyze CDC42 in different cell types makes it a versatile tool for understanding the complex pathways in which CDC42 is involved.
Product Name:
CDC42 Rabbit Polyclonal Antibody
SKU:
CAB15657
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human CDC42 (NP_001782.1).
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
Purification Method:
Affinity purification
Gene ID:
998
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using CDC42 antibody (CAB15657) at dilution of 1:100. Blue: DAPI for nuclear staining.
