The CERS4 Polyclonal Antibody (PACO23283) is a valuable tool for researchers studying CERS4, a crucial enzyme involved in ceramide synthesis. This antibody, developed and validated for use in Western blotting and other immunological applications, specifically recognizes the CERS4 protein in human samples.CERS4, also known as ceramide synthase 4, is essential for maintaining lipid homeostasis and cellular integrity. Dysregulation of CERS4 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.
By targeting CERS4 with this antibody, researchers can investigate its role in disease pathogenesis and potentially uncover novel therapeutic targets.With its high specificity and sensitivity, the CERS4 Polyclonal Antibody (PACO23283) is a valuable tool for advancing our understanding of lipid metabolism and its implications in health and disease. Whether studying cell signaling pathways, lipid biology, or disease mechanisms, this antibody provides reliable and reproducible results for a wide range of research applications.
Synthesized peptide derived from internal of human LASS4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, Jurkat cells and HUVEC cells, using LASS4 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using LASS4 antibody.
Background:
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner By similarity.
Synonyms:
LAG1 longevity assurance homolog 4; LASS4;
UniProt Protein Function:
Lass4: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.Protein type: Membrane protein, multi-pass; Membrane protein, integral; DNA-bindingChromosomal Location of Human Ortholog: 19p13.2Cellular Component: endoplasmic reticulum; endoplasmic reticulum membraneMolecular Function: sphingosine N-acyltransferase activityBiological Process: ceramide biosynthetic process; sphingolipid biosynthetic process
