The CHTOP Antibody (PACO08094) is a high-quality polyclonal antibody designed for research involving CHTOP, a protein involved in regulating gene expression and RNA processing. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it suitable for a variety of research applications.CHTOP is known to play important roles in various cellular processes, including transcriptional regulation and mRNA splicing. By targeting CHTOP with this antibody, researchers can study the function and localization of this protein in different cell types, providing valuable insights into its role in normal cellular function and disease pathogenesis.
The CHTOP Antibody (PACO08094) is validated for use in Western blotting, immunofluorescence, and immunohistochemistry applications, allowing for flexible and reliable detection and analysis of CHTOP in experimental settings. With its versatility and specificity, this antibody is an essential tool for studying the molecular mechanisms underlying gene expression regulation and RNA processing.
chromosome 1 open reading frame 77;C1orf77;DKFZp547E1010;MGC131924;MGC86949;RP1-178F15.2;pp7704 ;
UniProt Protein Function:
CHTOP: Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. 3 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-binding; NucleolusChromosomal Location of Human Ortholog: 1q21.3Cellular Component: intracellular membrane-bound organelle; nuclear speck; nucleoplasmMolecular Function: methyl-CpG binding; protein bindingBiological Process: mRNA 3'-end processing; mRNA export from nucleus; positive regulation of ATPase activity; positive regulation of cell proliferation; positive regulation of helicase activity; positive regulation of histone methylation; RNA export from nucleus; termination of RNA polymerase II transcription
UniProt Protein Details:
NCBI Summary:
This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]
