The CIB2 Polyclonal Antibody (PACO03346) is a valuable tool for researchers studying CIB2, a calcium and integrin binding protein that plays a crucial role in various cellular functions. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CIB2 protein, this antibody allows for the detection and analysis of CIB2 expression in different cell types, making it ideal for studies related to cell signaling, calcium binding, and integrin interactions.
CIB2 is known for its involvement in sensory transduction and has been linked to conditions such as Usher syndrome and deafness. Research into CIB2 is essential for understanding its role in these diseases and potentially identifying therapeutic targets for treatment. The CIB2 Polyclonal Antibody provides researchers with a reliable tool for investigating the functions and mechanisms of CIB2, ultimately advancing our knowledge of its implications in human health and disease.
Antibody Name:
CIB2 Antibody
Antibody SKU:
PACO03346
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human CIB2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CIB2; KIP2; Calcium and integrin-binding family member 2; Kinase-interacting protein 2; KIP 2
UniProt Protein Function:
CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction processProtein type: Calcium-bindingChromosomal Location of Human Ortholog: 15q24Cellular Component: cytoplasm; photoreceptor inner segment; photoreceptor outer segment; stereociliumMolecular Function: calcium ion binding; magnesium ion binding; protein binding; protein homodimerization activityBiological Process: calcium ion homeostasis; elevation of cytosolic calcium ion concentration; photoreceptor cell maintenanceDisease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
