The CIB2 Polyclonal Antibody (PAC021704) is a high-quality research tool designed for the study of Calcium and Integrin Binding Protein 2 (CIB2). This antibody is produced in rabbits and is highly specific to human samples, making it an ideal choice for researchers working in the fields of cell biology and molecular biology.CIB2 is a protein that plays a role in calcium signaling and integrin-mediated cell adhesion. It is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. The CIB2 Polyclonal Antibody binds specifically to CIB2 protein, allowing for the accurate detection and analysis of CIB2 expression in different cell types and experimental conditions.
Researchers studying diseases related to calcium dysregulation, integrin dysfunction, or abnormal cell signaling pathways may find the CIB2 Polyclonal Antibody particularly useful. Its ability to target CIB2 with high specificity and sensitivity makes it a valuable tool for investigating the functions and mechanisms of this important protein in various biological contexts.
Antibody Name:
CIB2 Antibody (PACO21704)
Antibody SKU:
PACO21704
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human CIB2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CIB2 antibody.
Synonyms:
Calcium and integrin-binding family member 2; Kinase-interacting protein 2; KIP 2; CIB2; KIP2
UniProt Protein Function:
CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction processProtein type: Calcium-bindingChromosomal Location of Human Ortholog: 15q24Cellular Component: cytoplasm; photoreceptor inner segment; photoreceptor outer segment; stereociliumMolecular Function: calcium ion binding; magnesium ion binding; protein binding; protein homodimerization activityBiological Process: calcium ion homeostasis; elevation of cytosolic calcium ion concentration; photoreceptor cell maintenanceDisease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
