The COX18 Polyclonal Antibody (PAC017717) is a valuable tool for research involving the study of COX18, a protein involved in mitochondrial biogenesis and membrane insertion. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the COX18 protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for investigations in the fields of mitochondrial biology and bioenergetics.COX18 plays a crucial role in the assembly and maintenance of the mitochondrial respiratory chain, which is essential for cellular energy production.
Dysregulation of COX18 has been associated with a variety of mitochondrial disorders and diseases, making it a key target for research in areas such as neurodegenerative disorders, metabolic diseases, and aging-related pathologies. Understanding the function and regulation of COX18 is vital for the development of potential therapies aimed at improving mitochondrial function and overall cellular health.
Antibody Name:
COX18 Antibody (PACO17717)
Antibody SKU:
PACO17717
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human COX18
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17717(COX18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17717(COX18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain.
Synonyms:
COX18 cytochrome C oxidase assembly factor
UniProt Protein Function:
COX18: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. Belongs to the OXA1/ALB3/YidC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 4q13.3Cellular Component: integral to mitochondrial inner membraneMolecular Function: protein transporter activityBiological Process: protein transport; protein insertion into mitochondrial membrane; respiratory chain complex IV assembly
UniProt Protein Details:
NCBI Summary:
This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
