| UniProt Protein Function: | COX18: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. Belongs to the OXA1/ALB3/YidC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 4q13.3Cellular Component: integral to mitochondrial inner membraneMolecular Function: protein transporter activityBiological Process: protein transport; protein insertion into mitochondrial membrane; respiratory chain complex IV assembly |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q8N8Q8 |
| NCBI GenInfo Identifier: | 38372495 |
| NCBI Gene ID: | 285521 |
| NCBI Accession: | Q8N8Q8.1 |
| UniProt Secondary Accession: | Q8N8Q8,Q2PB66, Q2PB67, Q2PB68, Q49B97, Q6IPP9 |
| UniProt Related Accession: | Q8N8Q8 |
| Molecular Weight: | 333 |
| NCBI Full Name: | Mitochondrial inner membrane protein COX18 |
| NCBI Synonym Full Names: | COX18 cytochrome c oxidase assembly factor |
| NCBI Official Symbol: | COX18Â Â |
| NCBI Official Synonym Symbols: | COX18HSÂ Â |
| NCBI Protein Information: | mitochondrial inner membrane protein COX18; cytochrome c oxidase assembly homolog 18; cytochrome c oxidase assembly protein 18 |
| UniProt Protein Name: | Mitochondrial inner membrane protein COX18 |
| UniProt Synonym Protein Names: | Cytochrome c oxidase assembly protein 18 |
| Protein Family: | Mitochondrial inner membrane protein |
| UniProt Gene Name: | COX18Â Â |
| UniProt Entry Name: | COX18_HUMAN |
