The CSH1 Polyclonal Antibody (CAB1972) is specifically designed for research involving the CSH1 protein, a critical hormone involved in mammalian pregnancy. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blotting and immunohistochemistry.CSH1, also known as placental lactogen, plays a crucial role in promoting growth and development during pregnancy by regulating maternal metabolism and facilitating nutrient transfer to the fetus. Its significance in reproductive biology makes it an essential target for studies in endocrinology, obstetrics, and developmental biology.
This polyclonal antibody binds specifically to CSH1, enabling accurate detection and analysis in various tissue types, making it ideal for investigating the role of CSH1 in normal pregnancy, pregnancy-related disorders, and fertility research. Understanding the function of CSH1 is vital for advancing knowledge in reproductive health and fostering the development of targeted therapies for pregnancy complications.
Recombinant fusion protein containing a sequence corresponding to amino acids 27-217 of human Placental lactogen (Placental lactogen (CSH1)) (NP_001308.1).
endoplasmic reticulum, endosome lumen, extracellular region, extracellular space
Calculated MW:
25kDa
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
Purification Method:
Affinity purification
Gene ID:
1442
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human liver using Placental lactogen (CSH1) Rabbit pAb (CAB1972) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
