The DNase1 Polyclonal Antibody (CAB14531) is a powerful tool for researchers studying DNase1, a key enzyme involved in DNA degradation and clearance. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for reliable use in Western blot applications. By specifically binding to the DNase1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and genetics.DNase1 is an essential enzyme with critical functions in maintaining cellular homeostasis by degrading DNA released during cell death and preventing autoimmune responses triggered by the accumulation of DNA fragments.
Research into DNase1 is vital for understanding its role in various diseases such as autoimmune disorders, cancer, and inflammatory conditions. The DNase1 Polyclonal Antibody provides researchers with a precise tool to investigate the expression and activity of DNase1, facilitating advancements in the development of therapeutic strategies targeting this enzyme.
Product Name:
DNASE1 Rabbit Polyclonal Antibody
SKU:
CAB14531
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human DNASE1 (NP_005214.2).
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Purification Method:
Affinity purification
Gene ID:
1773
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of C6 cells using DNASE1 Rabbit pAb (CAB14531) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
