The Ectodysplasin A Polyclonal Antibody (CAB2905) is a specialized research tool designed for investigators studying the Ectodysplasin A protein, an important molecule involved in skin development and maintenance. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various experimental techniques, including Western blot analysis.Ectodysplasin A is a key regulator of ectodermal tissue development, playing a critical role in the formation of hair, teeth, and sweat glands. Dysregulation of Ectodysplasin A has been associated with a variety of genetic disorders characterized by abnormalities in ectodermal structures.
Therefore, researchers studying developmental biology, dermatology, and genetic diseases will find this antibody invaluable for investigating the functions and mechanisms of Ectodysplasin A.By specifically targeting Ectodysplasin A, researchers can gain insights into the molecular pathways underlying ectodermal tissue development, offering new opportunities for therapeutic interventions in conditions related to skin, hair, and teeth abnormalities. The Ectodysplasin A Polyclonal Antibody (CAB2905) is a crucial tool for advancing our understanding of ectodermal biology and its implications for human health and disease.
Product Name:
EDA Rabbit Polyclonal Antibody
SKU:
CAB2905
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 62-182 of human EDA (NP_001390.1).
Cell membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
41kDa
Observed MW:
41kDa
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1896
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using EDA Rabbit pAb (CAB2905) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
