The Endothelin-3 Polyclonal Antibody (CAB1045) is specifically designed for research involving the Endothelin-3 protein, a key player in the regulation of blood vessel constriction and cell proliferation. This antibody is raised in rabbits and is highly reactive with human samples, making it a powerful tool for studying the function and activity of Endothelin-3 in various biological processes.Endothelin-3 is known for its involvement in cardiovascular function, making it an important target for research in cardiology and vascular biology. By binding to the Endothelin-3 protein, this antibody enables researchers to detect and analyze its presence in different cell types and tissues, allowing for a deeper understanding of its role in health and disease.
With its validated use in Western blot applications, the Endothelin-3 Polyclonal Antibody is ideal for studies in cardiovascular diseases, cancer research, and other fields where Endothelin-3 is implicated. By investigating the function of Endothelin-3, researchers can uncover new insights into the mechanisms of disease and develop targeted therapies to address cardiovascular disorders and other related conditions.
Product Name:
EDN3 Rabbit Polyclonal Antibody
SKU:
CAB1045
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-187 of human EDN3 (NP_996917.1).
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
1908
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of A-549 cells, using EDN3 antibody (CAB1045) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 20s.
