The EPS8L2 Polyclonal Antibody (PACO06469) is a valuable tool for researchers studying EPS8L2, a protein involved in cell signaling and cytoskeleton regulation. This antibody, produced in rabbits, is highly specific to human EPS8L2 and has been validated for use in Western blot applications. By targeting the EPS8L2 protein, this antibody allows for the detection and analysis of EPS8L2 in various cell types, making it ideal for studies in cell biology and cancer research.
EPS8L2 is known to play a role in cell migration and invasion, making it a potential target for therapeutic interventions in cancer metastasis. Understanding the function of EPS8L2 is essential for unraveling its involvement in tumorigenesis and identifying novel treatment strategies. The EPS8L2 Polyclonal Antibody provides researchers with a reliable tool for investigating the role of EPS8L2 in various cellular processes and diseases.
Synthesized peptide derived from the N-terminal region of human Eps8L2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of A549 K562 cells using Eps8L2 Polyclonal Antibody.
Western Blot analysis of Hela cells using Eps8L2 Polyclonal Antibody.
Synonyms:
EPS8L2; EPS8R2; PP13181; Epidermal growth factor receptor kinase substrate 8-like protein 2; EPS8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-related protein 2
UniProt Protein Function:
EPS8L2: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Belongs to the EPS8 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Actin-binding; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; plasma membrane; protein complex; vesicleMolecular Function: actin binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activityBiological Process: regulation of Rho protein signal transduction; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]
