The EPS8L2 Polyclonal Antibody (PACO21955) is a valuable tool for researchers studying EPS8L2, a protein involved in cell signaling and actin filament regulation. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in various applications, including Western blotting and immunofluorescence.EPS8L2, a member of the EPS8 family, plays a crucial role in cellular processes such as cell migration, adhesion, and proliferation. By binding specifically to EPS8L2, this antibody enables the detection and analysis of the protein in different cell types, making it ideal for research in cell biology, cancer biology, and developmental biology.
Understanding the functions of EPS8L2 is essential for unraveling its role in disease pathogenesis, particularly in cancer progression and metastasis. The EPS8L2 Polyclonal Antibody provides researchers with a reliable tool to investigate the molecular mechanisms underlying EPS8L2-mediated cellular processes, paving the way for the development of targeted therapies in various pathological conditions.
Antibody Name:
EPS8L2 Antibody (PACO21955)
Antibody SKU:
PACO21955
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human ES8L2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from HeLa cells, Jurkat cells and HUVEC cells, using ES8L2 antibody.
Synonyms:
Epidermal growth factor receptor kinase substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-like protein 2; EPS8L2; EPS8R2
UniProt Protein Function:
EPS8L2: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Belongs to the EPS8 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Actin-binding; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; plasma membrane; protein complex; vesicleMolecular Function: actin binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activityBiological Process: regulation of Rho protein signal transduction; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]
