Description
ERF Antibody (PACO06474)
The ERF Polyclonal Antibody (PACO6474) is a valuable tool for researchers studying the ERF protein, a transcription factor with key roles in cellular processes such as growth, development, and response to stress. This antibody is produced in rabbits and is highly specific for human samples, making it an essential tool for studies involving ERF protein expression and localization.The ERF antibody is validated for use in Western blot applications, allowing for the detection and analysis of ERF protein levels in various cell types and tissues. Its high reactivity and specificity make it an ideal choice for immunology and cancer research, where ERF has been implicated in cancer progression and treatment resistance.
The ERF protein, also known as Ets2 repressor factor, is a critical regulator of gene expression and cellular function. Dysregulation of ERF has been linked to various diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases. By understanding the role of ERF in these pathologies, researchers can develop targeted therapies that exploit the functions of this protein for therapeutic benefit.
| Antibody Name: | ERF Antibody (PACO06474) |
| Antibody SKU: | PACO06474 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from human ERF around the non-phosphorylation site of T526. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of NIH-3T3 A549 cells using ERF Polyclonal Antibody. |
 | Western Blot analysis of HepG2 cells using ERF Polyclonal Antibody. |
| Synonyms: | ERF; ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE-2 |
| UniProt Protein Function: | ERF: potent transcriptional repressor that binds to the H1 element of the ETS2 promoter. Belongs to the ETS family of transcription factors. Its function is regulated by phosphorylation. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 19q13 Cellular Component: cytosol; Golgi apparatus; nucleoplasm; nucleus Molecular Function:sequence-specific DNA binding; transcription corepressor activity Biological Process: cell cycle; cell differentiation; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent Disease: Craniosynostosis 4 |
| NCBI Summary: | ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P50548 |
| NCBI GenInfo Identifier: | 50403684 |
| NCBI Gene ID: | 2077 |
| NCBI Accession: | P50548.2 |
| UniProt Secondary Accession: | P50548,Q59G38, Q9UPI7, B2RAP1, B7Z4R0, |
| UniProt Related Accession: | P50548 |
| Molecular Weight: | 49,965 Da |
| NCBI Full Name: | ETS domain-containing transcription factor ERF |
| NCBI Synonym Full Names: | ETS2 repressor factor |
| NCBI Official Symbol: | ERFÂ Â |
| NCBI Official Synonym Symbols: | PE2; CRS4; PE-2Â Â |
| NCBI Protein Information: | ETS domain-containing transcription factor ERF |
| UniProt Protein Name: | ETS domain-containing transcription factor ERF |
| UniProt Synonym Protein Names: | Ets2 repressor factor; PE-2 |
| Protein Family: | Essential recombination function protein |
| UniProt Gene Name: | ERFÂ Â |
| UniProt Entry Name: | ERF_HUMAN |
| Antibodies | ELISA Kits |
| Phospho-ERF (T526) Antibody (PACO03638) | ERF Transcription Factor Activity Assay |
| ERF Antibody (PACO03639) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
