The FOLH1b Antibody (PAC019674) is a highly specific antibody designed for research involving FOLH1b, a cell surface protein associated with various physiological and pathological conditions. The antibody, generated using advanced technology, is optimized for use in immunohistochemistry applications and is highly sensitive in detecting FOLH1b protein expression in tissue samples. It binds specifically to FOLH1b, allowing for precise localization and quantification in different tissues and cell types, making it an essential tool for studies in cancer biology and neurology.
FOLH1b, also known as prostate-specific membrane antigen (PSMA), is a promising biomarker for prostate cancer diagnosis and prognosis, as well as a potential target for novel cancer therapies. Its overexpression in various cancer types and association with tumor aggressiveness make it a focus of research in precision medicine and personalized cancer treatment approaches. Understanding the role of FOLH1b in tumor growth and metastasis is crucial for developing effective strategies for cancer diagnosis and treatment.
Antibody Name:
FOLH1B Antibody (PACO19674)
Antibody SKU:
PACO19674
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human FOLH1B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19674(FOLH1B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19674(FOLH1B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
PSM is an integral membrane protein, and PCTA-1 is related to the galectin gene family, which mediate both cell-cell and cell-matrix interactions in a manner similar to the selectin subgroup of C-type lectins. STEAP is a serpentine transmembrane cell-surface tumor-antigen that is predicted to functions as a channel or transporter protein. In addition to prostate cancers, STEAP is also upregulated in bladder, colon and ovarian cancers.
Synonyms:
folate hydrolase 1B
UniProt Protein Function:
PSMAL: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Belongs to the peptidase M28 family. M28B subfamily.Protein type: EC 3.4.-.-Chromosomal Location of Human Ortholog: 11q14.3Cellular Component: plasma membraneMolecular Function: dipeptidase activity; metallocarboxypeptidase activityBiological Process: amino acid biosynthetic process
