The FUS Polyclonal Antibody (CAB21830) is a high-quality antibody developed for reliable detection and analysis of target proteins. The antibody, produced in rabbits, shows strong reactivity with human samples and is validated for use in Western blot applications. By targeting the FUS protein, this antibody enables researchers to detect and analyze FUS expression in a variety of cell types, making it well-suited for studies in neurobiology, oncology, and developmental biology.FUS, also known as fused in sarcoma, has been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), highlighting its importance in neuronal function and disease pathology.
This antibody is validated for use in WB, IHC-P, IP, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
FUS Polyclonal Antibody
SKU:
CAB21830
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
Purification Method
Affinity purification
Gene ID
2521
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using FUS Rabbit pAb (CAB21830) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Immunohistochemistry analysis of paraffin-embedded Mouse brain using FUS Rabbit pAb (CAB21830) at dilution of 1:25 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Immunoprecipitation analysis of 300 μg extracts of Jurkat cells using 3 μg FUS antibody (CAB21830). Western blot was performed from the immunoprecipitate using FUS (CAB21830) at a dilution of 1:1000.
