The GPR124 Monoclonal Antibody (PACO19730) is a powerful tool for research involving GPR124, a crucial regulator of blood-brain barrier integrity and angiogenesis. This antibody, produced in mice, is highly specific for human GPR124 and has been validated for use in various applications, including immunohistochemistry and flow cytometry.GPR124, also known as the adhesion G protein-coupled receptor, plays a key role in maintaining the integrity of the blood-brain barrier, which is essential for protecting the central nervous system. Additionally, GPR124 is involved in angiogenesis, the process of forming new blood vessels from pre-existing ones, making it a potential target for therapeutic interventions in conditions such as cancer and neurological disorders.
By utilizing the GPR124 Monoclonal Antibody, researchers can investigate the function and expression of GPR124 in different cell types and tissues, advancing our understanding of its role in various physiological and pathological processes. This antibody is a valuable tool for studies in neuroscience, oncology, and vascular biology, providing insights that may lead to the development of novel treatments for diseases related to blood-brain barrier dysfunction and abnormal angiogenesis.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19730(GPR124 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse bladder tissue, Primary antibody: PACO19730(GPR124 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19730(GPR124 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.
Synonyms:
G protein-coupled receptor 124
UniProt Protein Function:
GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 8p11.23Cellular Component: cell surface; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; regulation of chemotaxis; central nervous system development; endothelial cell migration; sprouting angiogenesis; regulation of angiogenesis
