Human CD83 Recombinant Protein (RPPB3096)
- SKU:
- RPPB3096
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q01151
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD83 Recombinant Protein |
| Product Code: | RPPB3096 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD83 |
| Synonyms: | BL11, HB15, hCD83, B-cell activation protein, Cell surface protein HB15. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD83 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTPEVKVA CSEDVDLPCT APWDPQVPYT VSWVKLLEGG EERMETPQED HLRGQHYHQK GQNGSFDAPN ERPYSLKIRN TTSCNSGTYR CTLQDPDGQR NLSGKVILRV TGCPAQRKEE TFKKYRAE |
CD83 is a single-pass type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 involves in the regulation of antigen presentation. A soluble form of CD83 can bind to dendritic cells and inhibit their maturation. There were 3 transcript variants encoding different isoforms for CD83.
CD83 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 148 amino acids (20-144a.a) and having a molecular mass of 16kDa. CD83 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD83: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p23 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Biological Process: negative regulation of interleukin-4 production; positive regulation of interleukin-2 production; defense response; positive regulation of CD4-positive, alpha beta T cell differentiation; signal transduction; response to organic cyclic substance; positive regulation of interleukin-10 production; humoral immune response |
| NCBI Summary: | The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q01151 |
| NCBI GenInfo Identifier: | 232223 |
| NCBI Gene ID: | 9308 |
| NCBI Accession: | Q01151.1 |
| UniProt Secondary Accession: | Q01151,Q5THX9, |
| UniProt Related Accession: | Q01151 |
| Molecular Weight: | 205 |
| NCBI Full Name: | CD83 antigen |
| NCBI Synonym Full Names: | CD83 molecule |
| NCBI Official Symbol: | CD83�� |
| NCBI Official Synonym Symbols: | BL11; HB15�� |
| NCBI Protein Information: | CD83 antigen; hCD83; B-cell activation protein; cell surface protein HB15; cell-surface glycoprotein; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) |
| UniProt Protein Name: | CD83 antigen |
| UniProt Synonym Protein Names: | B-cell activation protein; Cell surface protein HB15; CD_antigen: CD83 |
| Protein Family: | CD83 antigen |
| UniProt Gene Name: | CD83�� |
| UniProt Entry Name: | CD83_HUMAN |
