Human CD84 Recombinant Protein (RPPB3098)
- SKU:
- RPPB3098
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UIB8
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD84 Recombinant Protein |
| Product Code: | RPPB3098 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD84 |
| Synonyms: | CD84 Molecule, Signaling Lymphocytic Activation Molecule 5, Leukocyte Differentiation Antigen CD84, CD84 Antigen (Leukocyte Antigen), Cell Surface Antigen MAX.3, Hly9-Beta, SLAMF5, Leucocyte Differentiation Antigen CD84, Leukocyte Antigen CD84, SLAM Family Member 5, CD84 Antigen, HCD84, MCD84, LY9B, SLAM family member 5, Cell surface antigen MAX.3, Hly9-beta, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD84 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPKDSEIFT VNGILGESVT FPVNIQEPRQ VKIIAWTSKT SVAYVTPGDS ETAPVVTVTH RNYYERIHAL GPNYNLVISD LRMEDAGDYK ADINTQADPY TTTKRYNLQI YRRLGKPKIT QSLMASVNST CNVTLTCSVE KEEKNVTYNW SPLGEEGNVL QIFQTPEDQE LTYTCTAQNPVSNNSDSISA RQLCADIAMG FRTHHTGHHH HHH |
CD84 belongs to the signaling lymphocyte activation molecule (SLAM) family which forms a subset of the greater CD2 cell-surface receptor Ig superfamily. CD84, a membrane glycoprotein, is a homophilic adhesion molecule found in various immune cells types and takes part in regulating receptor-mediated signaling in those cells.
CD84 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 213 amino acids (22-225 a.a.) and having a molecular mass of 23.8kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).CD84 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD84: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily; Motility/polarity/chemotaxis; Cell surface Chromosomal Location of Human Ortholog: 1q24 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding Biological Process: adaptive immune response; blood coagulation; defense response; homophilic cell adhesion; innate immune response; leukocyte migration; negative regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of interleukin-18 production; negative regulation of mast cell activation; negative regulation of mast cell degranulation |
| NCBI Summary: | This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9UIB8 |
| NCBI GenInfo Identifier: | 74762772 |
| NCBI Gene ID: | 8832 |
| NCBI Accession: | Q9UIB8.1 |
| UniProt Secondary Accession: | Q9UIB8,O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1 Q8WWI8, Q9UF04, Q9UIB6, B2R8T1, B7Z3R8, |
| UniProt Related Accession: | Q9UIB8 |
| Molecular Weight: | 24,025 Da |
| NCBI Full Name: | SLAM family member 5 |
| NCBI Synonym Full Names: | CD84 molecule |
| NCBI Official Symbol: | CD84�� |
| NCBI Official Synonym Symbols: | LY9B; hCD84; mCD84; SLAMF5�� |
| NCBI Protein Information: | SLAM family member 5 |
| UniProt Protein Name: | SLAM family member 5 |
| UniProt Synonym Protein Names: | Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD_antigen: CD84 |
| Protein Family: | SLAM family |
| UniProt Gene Name: | CD84�� |
| UniProt Entry Name: | SLAF5_HUMAN |
