Human CDKN2C Recombinant Protein (RPPB2468)
- SKU:
- RPPB2468
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P42773
- Research Area:
- Enzymes
Description
| Product Name: | Human CDKN2C Recombinant Protein |
| Product Code: | RPPB2468 |
| Size: | 20µg |
| Species: | Human |
| Target: | CDKN2C |
| Synonyms: | Cyclin-dependent kinase inhibitor 2C (p18 inhibits CDK4), cyclin-dependent kinase 4 inhibitor C, cyclin-dependent kinase 6 inhibitor p18, INK4C, p18, p18-INK6, p18-INK4C, CDK6 inhibitor p18, cyclin-dependent inhibitor, CDKN6, p18-INK4c. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CDKN2C solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ |
CDKN2C is a member of the CDKN2 cyclin-dependent kinase inhibitor family. CDKN2C cooperates with CDK4 or CDK6, and inhibits the activation of the CDK kinases, therefore acts as a cell growth regulator which regulates cell cycle G1 progression. CDKN2C suppresses the cell growth and proliferation with a correlated dependency on endogenous retinoblastoma protein RB. Studies in the knockout mice show CDKN2C takes part in regulating spermatogenesis, in addition to suppressing tumorigenesis.
CDKN2C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-168 and having a molecular mass of 20.7kDa.CDKN2C is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
| NCBI Summary: | The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P42773 |
| NCBI GenInfo Identifier: | 1168870 |
| NCBI Gene ID: | 1031 |
| NCBI Accession: | P42773.1 |
| UniProt Secondary Accession: | P42773,Q8TB83, |
| UniProt Related Accession: | P42773 |
| Molecular Weight: | 18kDa |
| NCBI Full Name: | Cyclin-dependent kinase 4 inhibitor C |
| NCBI Synonym Full Names: | cyclin dependent kinase inhibitor 2C |
| NCBI Official Symbol: | CDKN2C�� |
| NCBI Official Synonym Symbols: | p18; INK4C; p18-INK4C�� |
| NCBI Protein Information: | cyclin-dependent kinase 4 inhibitor C |
| UniProt Protein Name: | Cyclin-dependent kinase 4 inhibitor C |
| UniProt Synonym Protein Names: | Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6 |
| Protein Family: | Cyclin-dependent kinase 4 inhibitor |
| UniProt Gene Name: | CDKN2C�� |
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