Human CMPK1 Recombinant Protein (RPPB2488)
- SKU:
- RPPB2488
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P30085
- Research Area:
- Enzymes
Description
| Product Name: | Human CMPK1 Recombinant Protein |
| Product Code: | RPPB2488 |
| Size: | 20µg |
| Species: | Human |
| Target: | CMPK1 |
| Synonyms: | UMP-CMP kinase, Cytidine monophosphate kinase, Cytidylate kinase, Deoxycytidylate kinase, Uridine monophosphate kinase, Uridine monophosphate/cytidine monophosphate kinase, UMP/CMP kinase, UMP/CMPK, CMPK1, CMK, CMPK, UCK, UMK, UMPK, UMP-CMPK, RP11-511I2.1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CMPK1 solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 1mM DTT and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MLSRCRSGLL HVLGLSFLLQ TRRPILLCSP RLMKPLVVFV LGGPGAGKGT QCARIVEKYG YTHLSAGELL RDERKNPDSQ YGELIEKYIK EGKIVPVEIT ISLLKREMDQ TMAANAQKNK FLIDGFPRNQ DNLQGWNKTM DGKADVSFVL FFDCNNEICI ERCLERGKSS GRSDDNRESL EKRIQTYLQS TKPIIDLYEE MGKVKKIDAS KSVDEVFDEV VQIFDKEG |
UMP-CMP kinase and deoxycytidylate kinase (CMPK1) is an enzyme which catalyzes the phosphoryl transfer from ATP to UMP, CMP and dCMP. This enzymatic reaction brings about the formation of ADP and the corresponding nucleoside diphosphate that are necessary for cellular nucleic acid synthesis. In addition, CMPK1 has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs.
CMPK1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 248 amino acids (1-228) and having a molecular mass of 28kDa. CMPK1 is fused to a�20 a.a His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CMPK: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP. Belongs to the adenylate kinase family. |
| UniProt Protein Details: | Protein type:EC 2.7.4.14; Nucleotide Metabolism - pyrimidine; EC 2.7.4.6; Kinase, other Chromosomal Location of Human Ortholog: 1p32 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:ATP binding; cytidylate kinase activity; nucleoside diphosphate kinase activity; uridine kinase activity; uridylate kinase activity Biological Process: 'de novo' pyrimidine base biosynthetic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; pyrimidine ribonucleotide biosynthetic process; UMP biosynthetic process |
| NCBI Summary: | This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012] |
| UniProt Code: | P30085 |
| NCBI GenInfo Identifier: | 12644008 |
| NCBI Gene ID: | 51727 |
| NCBI Accession: | P30085.3 |
| UniProt Secondary Accession: | P30085,Q53GB7, Q5SVZ0, Q96C07, Q9UBQ8, Q9UIA2, B4DPU7 E9PGI8, |
| UniProt Related Accession: | P30085 |
| Molecular Weight: | 16,548 Da |
| NCBI Full Name: | UMP-CMP kinase |
| NCBI Synonym Full Names: | cytidine/uridine monophosphate kinase 1 |
| NCBI Official Symbol: | CMPK1�� |
| NCBI Official Synonym Symbols: | CK; CMK; UMK; CMPK; UMPK; UMP-CMPK�� |
| NCBI Protein Information: | UMP-CMP kinase |
| UniProt Protein Name: | UMP-CMP kinase |
| UniProt Synonym Protein Names: | Deoxycytidylate kinase |
| UniProt Gene Name: | CMPK1�� |
| UniProt Entry Name: | KCY_HUMAN |
