Human CRTAM Recombinant Protein (RPPB3266)
- SKU:
- RPPB3266
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95727
- Research Area:
- CD Antigens
Frequently bought together:
Description
| Product Name: | Human CRTAM Recombinant Protein |
| Product Code: | RPPB3266 |
| Size: | 10µg |
| Species: | Human |
| Target: | CRTAM |
| Synonyms: | Cytotoxic and Regulatory T Cell Molecule, Class I MHC Restricted T Cell Associated Molecule, Class-I MHC-Restricted T-Cell-Associated Molecule, Class-I MHC-Restricted T Cell Associated Molecule, Cytotoxic and Regulatory T-Cell Molecule, CD355 Antigen, CD355. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterilefiltered colorless solution. |
| Formulation: | CRTAM protein solution (1mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% asdetermined by SDS-PAGE. |
| Amino Acid Sequence: | SLTNHTETIT VEEGQTLTLKCVTSLRKNSS LQWLTPSGFT IFLNEYPALK NSKYQLLHHS ANQLSITVPN VTLQDEGVYK CLHYSDSVSTKEVKVIVLAT PFKPILEASV IRKQNGEEHV VLMCSTMRSK PPPQITWLLG NSMEVSGGTL HEFETDGKKCNTTSTLIIHT YGKNSTVDCI IRHRGLQGRK LVAPFRFEDL VTDEETASDA LERNSLSSQD PQQPTSTVSV TEDSSTSEIDKEEKEQTTQD PDLTTEANPQ YLGLARKKSG LEHHHHHH |
Cytotoxic and Regulatory T Cell Molecule, also known as CRTAM belongs to the immunoglobulin superfamily which complies with the structural characteristics of the JAM family and is phylogenetically more closely related to nectin-like proteins. CRTAM is implicated in epithelial cell adhesion. Furthermore, CRTAM interacts with CADM1 as well as promotes natural killer (NK) cell cytotoxicity.
CRTAM produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 278 amino acids (18-287 a.a.) and having a molecular mass of 31.0kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).CRTAM is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CRTAM: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Apoptosis; Membrane protein, integralChromosomal Location of Human Ortholog: 11q24.1Cellular Component: integral to membrane; plasma membraneMolecular Function: receptor bindingBiological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; detection of tumor cell; activated T cell proliferation; detection of stimulus; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity; positive regulation of cytokine secretion |
| UniProt Protein Details: | |
| NCBI Summary: | The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009] |
| UniProt Code: | O95727 |
| NCBI GenInfo Identifier: | 755571554 |
| NCBI Gene ID: | 56253 |
| NCBI Accession: | NP_001291711.1 |
| UniProt Secondary Accession: | O95727,Q59EI1, Q6IRX2 |
| UniProt Related Accession: | O95727 |
| Molecular Weight: | 22,256 Da |
| NCBI Full Name: | cytotoxic and regulatory T-cell molecule Isoform 2 |
| NCBI Synonym Full Names: | cytotoxic and regulatory T cell molecule |
| NCBI Official Symbol: | CRTAM�� |
| NCBI Official Synonym Symbols: | CD355�� |
| NCBI Protein Information: | cytotoxic and regulatory T-cell molecule; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; class-I MHC-restricted T-cell-associated molecule |
| UniProt Protein Name: | Cytotoxic and regulatory T-cell molecule |
| UniProt Synonym Protein Names: | Class-I MHC-restricted T-cell-associated molecule; CD_antigen: CD355 |
| Protein Family: | Cytotoxic and regulatory T-cell molecule |
| UniProt Gene Name: | CRTAM�� |
| UniProt Entry Name: | CRTAM_HUMAN |
