Description
| Product Name: | Human CUEDC2 Recombinant Protein |
| Product Code: | RPPB3311 |
| Size: | 20µg |
| Species: | Human |
| Target: | CUEDC2 |
| Synonyms: | CUE domain-containing protein 2, CUEDC2, C10orf66, HOYS6, bA18I14.5. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CUEDC2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMELERIV SAALLAFVQT HLPEADLSGL DEVIFSYVLG VLEDLGPSGP SEENFDMEAF TEMMEAYVPG FAHIPRGTIG DMMQKLSGQL SDARNKENLQ PQSSGVQGQV PISPEPLQRP EMLKEETRSS AAAAADTQDE ATGAEEELLP GVDVLLEVFP TCSVEQAQWV LAKARGDLEE AVQMLVEGKE EGPAAWEGPN QDLPRRLRGP QKDELKSFIL QKYMMVDSAE DQKIHRPMAP KEAPKKLIRY IDNQVVSTKG ERFKDVRNPE AEEMKATYIN LKPARKYRFH |
CUE Domain Containing 2 also known as CUEDC2 is a part of the CUEDC2 family and contains 1 CUE domain. CUEDC2 down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway and controls PGR protein levels through a parallel mechanism.
CUEDC2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 310 amino acids (1-287) and having a molecular mass of 34 kDa.CUEDC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CUEDC2: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression. Belongs to the CUEDC2 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q24.32 Cellular Component: cytoplasm; nuclear membrane; nucleoplasm Molecular Function:protein binding |
| UniProt Code: | Q9H467 |
| NCBI GenInfo Identifier: | 74752634 |
| NCBI Gene ID: | 79004 |
| NCBI Accession: | Q9H467.1 |
| UniProt Secondary Accession: | Q9H467,Q9BWG8, D3DR88, |
| UniProt Related Accession: | Q9H467 |
| Molecular Weight: | 32,009 Da |
| NCBI Full Name: | CUE domain-containing protein 2 |
| NCBI Synonym Full Names: | CUE domain containing 2 |
| NCBI Official Symbol: | CUEDC2�� |
| NCBI Official Synonym Symbols: | C10orf66; bA18I14.5�� |
| NCBI Protein Information: | CUE domain-containing protein 2 |
| UniProt Protein Name: | CUE domain-containing protein 2 |
| Protein Family: | CUE domain-containing protein |
| UniProt Gene Name: | CUEDC2�� |
| UniProt Entry Name: | CUED2_HUMAN |
