Human EIF4EBP2 Recombinant Protein (RPPB3434)
- SKU:
- RPPB3434
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13542
Description
| Product Name: | Human EIF4EBP2 Recombinant Protein |
| Product Code: | RPPB3434 |
| Size: | 20µg |
| Species: | Human |
| Target: | EIF4EBP2 |
| Synonyms: | Eukaryotic Translation Initiation Factor 4E Binding Protein 2, 4E-BP2, eIF4E-binding protein 2, 4EBP2, PHASII, phosphorylated. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The EIF4EBP2 protein solution (0.5mg/ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 100mM NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSSSAGSGHQ PSQSRAIPTR TVAISDAAQL PHDYCTTPGG TLFSTTPGGT RIIYDRKFLL DRRNSPMAQT PPCHLPNIPG VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQFEMDI |
EIF4EBP2 belongs to the eukaryotic translation initiation factor 4E binding protein family. Even though EIF4EBP2 protein binds eIF4E and inhibits translation initiation, growth factors can release this inhibition by a phosphorylation-dependent disruption. EIF4EBP2 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. Regulation of this protein is associated to cell proliferation, cell differentiation and viral infection.
EIF4EBP2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 140amino acids (1-120a.a.) and having a molecular mass of 15.1 kDa. EIF4EBP2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | 4E-BP2: eukaryotic translation initiation factor 4E binding protein 2 |
| UniProt Protein Details: | Protein type:Translation; Translation initiation Chromosomal Location of Human Ortholog: 10q21-q22 Cellular Component: cytoplasm Molecular Function:eukaryotic initiation factor 4E binding; protein binding; translation repressor activity Biological Process: cAMP-mediated signaling; insulin receptor signaling pathway; memory; negative regulation of translational initiation; regulation of synaptic plasticity; regulation of synaptic transmission; social behavior; TOR signaling pathway; translation |
| NCBI Summary: | This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q13542 |
| NCBI GenInfo Identifier: | 34921510 |
| NCBI Gene ID: | 1979 |
| NCBI Accession: | Q13542.1 |
| UniProt Related Accession: | Q13542 |
| Molecular Weight: | 12,939 Da |
| NCBI Full Name: | Eukaryotic translation initiation factor 4E-binding protein 2 |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 4E binding protein 2 |
| NCBI Official Symbol: | EIF4EBP2�� |
| NCBI Official Synonym Symbols: | 4EBP2; PHASII�� |
| NCBI Protein Information: | eukaryotic translation initiation factor 4E-binding protein 2 |
| UniProt Protein Name: | Eukaryotic translation initiation factor 4E-binding protein 2 |
| UniProt Gene Name: | EIF4EBP2�� |
| UniProt Entry Name: | 4EBP2_HUMAN |
