Description
| Product Name: | Human GNAQ Recombinant Protein |
| Product Code: | RPPB3403 |
| Size: | 20µg |
| Species: | Human |
| Target: | GNAQ |
| Synonyms: | Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide,Guanine Nucleotide-Binding Protein Alpha-Q, CMC1, SWS, GAQ, GuanineNucleotide-Binding Protein G(Q) Subunit Alpha, G-ALPHA-Q, Guaninenucleotide-binding protein G(q) subunit alpha. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | GNAQ protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMTLESIM ACCLSEEAKE ARRINDEIER QLRRDKRDAR RELKLLLLGTGESGKSTFIK QMRIIHGSGY SDEDKRGFTK LVYQNIFTAM QAMIRAMDTL KIPYKYEHNK AHAQLVREVDVEKVSAFENP YVDAIKSLWN DPGIQECYDR RREYQLSDSTKYYLNDLDRV ADPAYLPTQQ DVLRVRVPTT GIIEYPFDLQ SVIFRMVDVGGQRSERRKWI HCFENVTSIM FLVALSEYDQ VLVESDNENR MEESKALFRT IITYPWFQNS SVILFLNKKDLLEEKIMYSH LVDYFPEYDG PQRDAQAARE FILKMFVDLN PDSDKIIYSH FTCATDTENIRFVFAAVKDT ILQLNLKEYN LV |
GNAQ, also known as Guanine nucleotide-binding protein belong to the G-alphafamily. Guanine nucleotide-binding proteins (G proteins) are involved asmodulators or transducers in a variety of transmembrane signaling systems. GNAQregulates B-cell selection and survival and is essential in order to preventB-cell-dependent autoimmunity. GNAQ also regulates chemotaxis of BM-derived neutrophilsand dendritic cells, in vitro. GNAQ is an alpha subunit in the Gq class,couples a seven-transmembrane domain receptor to activation ofphospolipase C-beta. Mutations at this locus have been connectedwith problems in platelet activation and aggregation. A related pseudogene toGNAQ exists on chromosome 2.
GNAQ Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 382 amino acids (1-359 a.a) andhaving a molecular mass of 44.5kDa.GNAQ is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. |
| UniProt Protein Details: | Protein type:G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G(q) Chromosomal Location of Human Ortholog: 9q21 Cellular Component: cytoplasm; lysosomal membrane; photoreceptor outer segment; plasma membrane Molecular Function:GTPase activator activity; GTPase activity; protein binding; type 2A serotonin receptor binding Biological Process: acetylcholine receptor signaling, muscarinic pathway; blood coagulation; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; G-protein signaling, adenylate cyclase activating pathway; glutamate signaling pathway; negative regulation of protein kinase activity; phospholipase C activation; phototransduction, visible light; platelet activation; protein stabilization; regulation of action potential Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome |
| NCBI Summary: | This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010] |
| UniProt Code: | P50148 |
| NCBI GenInfo Identifier: | 251757492 |
| NCBI Gene ID: | 2776 |
| NCBI Accession: | P50148.4 |
| UniProt Secondary Accession: | P50148,O15108, Q13462, Q6NT27, Q92471, Q9BZB9, |
| UniProt Related Accession: | P50148 |
| Molecular Weight: | 42,142 Da |
| NCBI Full Name: | Guanine nucleotide-binding protein G(q) subunit alpha |
| NCBI Synonym Full Names: | G protein subunit alpha q |
| NCBI Official Symbol: | GNAQ�� |
| NCBI Official Synonym Symbols: | GAQ; SWS; CMC1; G-ALPHA-q�� |
| NCBI Protein Information: | guanine nucleotide-binding protein G(q) subunit alpha |
| UniProt Protein Name: | Guanine nucleotide-binding protein G(q) subunit alpha |
| UniProt Synonym Protein Names: | Guanine nucleotide-binding protein alpha-q |
| UniProt Gene Name: | GNAQ�� |
| UniProt Entry Name: | GNAQ_HUMAN |
