Human HLA-G Recombinant Protein (RPPB3692)
- SKU:
- RPPB3692
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P17693
Description
| Product Name: | Human HLA-G Recombinant Protein |
| Product Code: | RPPB3692 |
| Size: | 10µg |
| Species: | Human |
| Target: | HLA-G |
| Synonyms: | Major Histocompatibility Complex, Class I, G, HLA-G Histocompatibility Antigen, Class I, G, MHC Class I Antigen G, B2 Microglobulin, HLA G Antigen, HLA Class I Histocompatibility Antigen, Alpha Chain G, Mutant MHC Class Ib Antigen, Mutant MHC Class I Antigen, MHC Class Ib Antigen, HLA-6.0, MHC-G, HLAG, HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, MHC class I antigen G. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | HLA-G protein solution (0.25mg/ml) contains 20% glycerol and�PBS (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMGSHSM RYFSAAVSRP GRGEPRFIAM GYVDDTQFVR FDSDSACPRM EPRAPWVEQE GPEYWEEETR NTKAHAQTDR MNLQTLRGYY NQSEASSHTL QWMIGCDLGS DGRLLRGYEQ YAYDGKDYLA LNEDLRSWTA ADTAAQISKR KCEAANVAEQ�RRAYLEGTCV EWLHRYLENG KEMLQRADPP KTHVTHHPVF DYEATLRCWA LGFYPAEIIL TWQRDGEDQT QDVELVETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPLMLRWK QSSLPTIPI |
HLA-G (Major Histocompatibility Complex Class I G) is a member of the HLA class I heavy chain paralogues. This class I molecule is a heterodimer which comprises a heavy chain as well as a light chain, beta-2 microglobulin, while the heavy chain is fixed in the membrane. HLA-G is expressed on fetal derived placental cells. HLA-G is a non-classical class-I HLA molecule linked with immuno-modulatory & anti-inflammatory properties which interacts with inhibitory receptors such as, ILT2/ILT4/KIR2DL4, that are present on different immune cells. HLA-G inhibits the proliferation of T cells, B cells & natural killer cells, moreover it also induces regulatory T cells.
HLA-G Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 309 amino acids (25-308 a.a) and having a molecular mass of 35.3kDa.HLA-G is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| NCBI Summary: | HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17693 |
| NCBI GenInfo Identifier: | 122132 |
| NCBI Gene ID: | 3135 |
| NCBI Accession: | P17693.1 |
| UniProt Related Accession: | P17693 |
| Molecular Weight: | Predicted Molecular Mass: 36.4kDaAccurate Molecular Mass: 38kDa as determined by SDS-PAGE reducing conditions. |
| NCBI Full Name: | HLA class I histocompatibility antigen, alpha chain G |
| NCBI Synonym Full Names: | major histocompatibility complex, class I, G |
| NCBI Official Symbol: | HLA-G�� |
| NCBI Official Synonym Symbols: | MHC-G�� |
| NCBI Protein Information: | HLA class I histocompatibility antigen, alpha chain G |
| UniProt Protein Name: | HLA class I histocompatibility antigen, alpha chain G |
| UniProt Synonym Protein Names: | HLA G antigen; MHC class I antigen G |
| UniProt Gene Name: | HLA-G�� |
| UniProt Entry Name: | HLAG_HUMAN |
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