Human IL 19 Recombinant Protein (RPPB0628)
- SKU:
- RPPB0628
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UHD0
- Research Area:
- Cytokines
Description
| Product Name: | Human IL 19 Recombinant Protein |
| Product Code: | RPPB0628 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL 19 |
| Synonyms: | Melanoma differentiation association like protein, MDA1, NG.1, ZMDA1, IL-10C, IL-19. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution in water containing 10mM sodium citrate pH-5. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin -19 in sterile 18M?-cm H2O at a concentration of 0.5mg/ml or less. |
| Stability: | Lyophilized Interleukin-19 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL19 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 99.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Arg-Arg-Cys |
| Biological Activity: | The activity is determined by it's ability to activate STAT following receptor-ligand interaction. |
IL19 is a cytokine that belongs to the IL10 cytokine subfamily. IL-19 is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
Interleukin-19 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of 17913 Dalton. The IL-19 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL19: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. |
| UniProt Protein Details: | Protein type:Apoptosis; Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 1q32.2 Cellular Component: extracellular space; extracellular region Molecular Function:cytokine activity Biological Process: apoptosis; positive regulation of JAK-STAT cascade; immune response; inflammatory response; signal transduction; interleukin-6 biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHD0 |
| NCBI GenInfo Identifier: | 146345440 |
| NCBI Gene ID: | 29949 |
| NCBI Accession: | Q9UHD0.2 |
| UniProt Secondary Accession: | Q9UHD0,Q5VUT3, Q96QR4, Q9NUA0, B6VEV9, |
| UniProt Related Accession: | Q9UHD0 |
| Molecular Weight: | 23,079 Da |
| NCBI Full Name: | Interleukin-19 |
| NCBI Synonym Full Names: | interleukin 19 |
| NCBI Official Symbol: | IL19�� |
| NCBI Official Synonym Symbols: | MDA1; NG.1; ZMDA1; IL-10C�� |
| NCBI Protein Information: | interleukin-19; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein |
| UniProt Protein Name: | Interleukin-19 |
| UniProt Synonym Protein Names: | Melanoma differentiation-associated protein-like protein; NG.1 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL19�� |
| UniProt Entry Name: | IL19_HUMAN |
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