Human IL10RA Recombinant Protein (RPPB0557)
- SKU:
- RPPB0557
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13651
- Research Area:
- Cytokines
Description
| Product Name: | Human IL10RA Recombinant Protein |
| Product Code: | RPPB0557 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL10RA |
| Synonyms: | Interleukin 10 Receptor, Alpha, IL10R, Interleukin-10 Receptor Subunit 1, IL-10 Receptor Subunit Alpha, IL-10R Subunit Alpha, IL-10R Subunit 1, CDW210A, IL-10R1, IL-10RA, Interleukin-10 Receptor Subunit Alpha, Interleukin-10 Receptor Alpha Chain, CD210 Antigen, HIL-10R, CD210a, CD210, IBD28, IL10RA. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The IL10RA protein solution (0.2mg/ml) containing Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSY DLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILG KIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS LLTSGEVGEF CVQVKPSVAS RSNKGMWSKE ECISLTRQYF TVTNHHHHHH |
IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
IL10RA Human Recombinant produced in�Sf9 Baculovirus cells is a single, non-glycosylated, polypeptide chain containing 220 amino acids (22-235 a.a.) and having a molecular mass of 25.2kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions).IL10RA is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 11q23 Cellular Component: integral to membrane; plasma membrane Molecular Function:interleukin-10 binding; interleukin-10 receptor activity; protein binding; receptor activity; signal transducer activity Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide Disease: Inflammatory Bowel Disease 28, Autosomal Recessive |
| NCBI Summary: | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q13651 |
| NCBI GenInfo Identifier: | 322510034 |
| NCBI Gene ID: | 3587 |
| NCBI Accession: | Q13651.2 |
| UniProt Secondary Accession: | Q13651,A8K6I0, B0YJ27, |
| UniProt Related Accession: | Q13651 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-10 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 10 receptor subunit alpha |
| NCBI Official Symbol: | IL10RA�� |
| NCBI Official Synonym Symbols: | CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1�� |
| NCBI Protein Information: | interleukin-10 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-10 receptor subunit alpha |
| UniProt Synonym Protein Names: | CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD_antigen: CD210 |
| Protein Family: | Interleukin-10 receptor |
| UniProt Gene Name: | IL10RA�� |
| UniProt Entry Name: | I10R1_HUMAN |
