Human IL17A Recombinant Protein (RPPB0598)
- SKU:
- RPPB0598
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16552
- Research Area:
- Cytokines
Description
| Product Name: | Human IL17A Recombinant Protein |
| Product Code: | RPPB0598 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL17A |
| Synonyms: | Interleukin 17A, CTLA8, IL17, Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8), Cytotoxic T-Lymphocyte-Associated Protein 8, Cytotoxic T-Lymphocyte-Associated Antigen 8, CTLA-8, IL-17A, IL-17, Interleukin-17A. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL17A protein solution (0.25mg/ml) contains Phosphate buffered saline (pH7.4), 20% glycerol, 1mM EDTA�and�0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VAHHHHHH |
IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
IL17A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (24-155 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 138 amino acids and having a molecular mass of 15.9kDa.IL17A shows multiple bands between 13.5-28kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p12 Cellular Component: extracellular space; external side of plasma membrane Molecular Function:cytokine activity Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; protein amino acid glycosylation; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response |
| NCBI Summary: | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16552 |
| NCBI GenInfo Identifier: | 2498481 |
| NCBI Gene ID: | 3605 |
| NCBI Accession: | Q16552.1 |
| UniProt Secondary Accession: | Q16552,Q5T2P0, |
| UniProt Related Accession: | Q16552 |
| Molecular Weight: | 17,504 Da |
| NCBI Full Name: | Interleukin-17A |
| NCBI Synonym Full Names: | interleukin 17A |
| NCBI Official Symbol: | IL17A�� |
| NCBI Official Synonym Symbols: | IL17; CTLA8; IL-17; IL-17A�� |
| NCBI Protein Information: | interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) |
| UniProt Protein Name: | Interleukin-17A |
| UniProt Synonym Protein Names: | Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL17A�� |
| UniProt Entry Name: | IL17_HUMAN |
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