Human IL17B Recombinant Protein (RPPB0601)
- SKU:
- RPPB0601
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UHF5
- Research Area:
- Cytokines
Description
| Product Name: | Human IL17B Recombinant Protein |
| Product Code: | RPPB0601 |
| Size: | 5µg |
| Species: | Human |
| Target: | IL17B |
| Synonyms: | Interleukin-17B, IL-17B, Cytokine Zcyto7, Interleukin-20, Neuronal interleukin-17-related factor, IL20, NIRF, ZCYTO7.� |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL17B protein solution (0.25mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPQPRSPKS KRKGQGRPGP LAPGPHQVPL DLVSRMKPYA RMEEYERNIE EMVAQLRNSS ELAQRKCEVN LQLWMSNKRS LSPWGYSINH DPSRIPVDLP EARCLCLGCV NPFTMQEDRS MVSVPVFSQV PVRRRLCPPP PRTGPCRQRA VMETIAVGCT CIFHHHHHH |
IL-17 family members are glycoproteins secreted as dimers which induce local cytokine production and recruit granulocytes to sites of inflammation. The IL-17 family is comprised of at least six pro-inflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 is induced by IL-15 and IL-23, mostly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL17B Diseases associated with IL17B include spondyloarthropathy, and neuronitis, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and STAT3 Pathway.
IL17B Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 169 amino acids (21-180a.a.) and having a molecular mass of 19.2kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). IL17B is expressed with a 6 amino acid His-tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. |
| NCBI Summary: | The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9UHF5 |
| NCBI GenInfo Identifier: | 20143877 |
| NCBI Gene ID: | 27190 |
| NCBI Accession: | Q9UHF5.1 |
| UniProt Secondary Accession: | Q9UHF5,Q14CE5, |
| UniProt Related Accession: | Q9UHF5 |
| Molecular Weight: | 20,437 Da |
| NCBI Full Name: | Interleukin-17B |
| NCBI Synonym Full Names: | interleukin 17B |
| NCBI Official Symbol: | IL17B�� |
| NCBI Official Synonym Symbols: | NIRF; IL-20; IL-17B; ZCYTO7�� |
| NCBI Protein Information: | interleukin-17B |
| UniProt Protein Name: | Interleukin-17B |
| UniProt Synonym Protein Names: | Cytokine Zcyto7; Interleukin-20; IL-20; Neuronal interleukin-17-related factor |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL17B�� |
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