Human IL3RA Recombinant Protein (RPPB0503)
- SKU:
- RPPB0503
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P26951
- Research Area:
- Cytokines
Description
| Product Name: | Human IL3RA Recombinant Protein |
| Product Code: | RPPB0503 |
| Size: | 5µg |
| Species: | Human |
| Target: | IL3RA |
| Synonyms: | Interleukin 3 Receptor Subunit Alpha, Interleukin 3 Receptor, Alpha (Low Affinity), IL-3 Receptor Subunit Alpha, IL-3R Subunit Alpha, CD123 Antigen, IL-3R-Alpha, IL-3RA, IL3R, Interleukin-3 Receptor Subunit Alpha, IL-3 Receptor Alpha SP2 Isoform, HIL-3Ra, IL3RAY, CD123, IL3RX, IL3RY, IL3RA. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL3RA protein solution (0.5mg/ml) contains 10% glycerol & Phosphate buffered saline (pH7.4).� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLKEDPNPP ITNLRMKAKA QQLTWDLNRN VTDIECVKDA DYSMPAVNNS YCQFGAISLC EVTNYTVRVA NPPFSTWILF PENSGKPWAG AENLTCWIHD VDFLSCSWAV GPGAPADVQY DLYLNVANRR QQYECLHYKT DAQGTRIGCR FDDISRLSSG SQSSHILVRG RSAAFGIPCTDKFVVFSQIE ILTPPNMTAK CNKTHSFMHW KMRSHFNRKF RYELQIQKRM QPVITEQVRD RTSFQLLNPG TYTVQIRARE RVYEFLSAWS TPQRFECDQE EGANTRAWRH HHHHH |
IL3RA, also known as Interleukin 3 Receptor Subunit Alpha, is a single-pass type 1 membrane protein which is a member of the type 1 cytokine receptor family as well as type 5 subfamily. IL3RA is a pleiotropic cytokine which is produced mainly by activated T cells or mast cells. Moreover, the specific alpha subunit of the interleukin 3 receptor is strongly expressed in a variety of leukemic blasts as well as leukemic stem cells and appears to be a great target for the therapy of leukemias.
IL3RA produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (20-305 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 295 amino acids and having a molecular mass of 34.1kDa.IL3RA shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL3RA: This is a receptor for interleukin-3. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3 Cellular Component: plasma membrane; integral to membrane Molecular Function:interleukin-3 receptor activity |
| NCBI Summary: | The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] |
| UniProt Code: | P26951 |
| NCBI GenInfo Identifier: | 417184 |
| NCBI Gene ID: | 3563 |
| NCBI Accession: | P26951.1 |
| UniProt Related Accession: | P26951 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-3 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 3 receptor subunit alpha |
| NCBI Official Symbol: | IL3RA�� |
| NCBI Official Synonym Symbols: | IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra�� |
| NCBI Protein Information: | interleukin-3 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-3 receptor subunit alpha |
| UniProt Synonym Protein Names: | CD_antigen: CD123 |
| Protein Family: | Interleukin-3 receptor |
| UniProt Gene Name: | IL3RA�� |
| UniProt Entry Name: | IL3RA_HUMAN |
