Description
| Product Name: | Human JDP2 Recombinant Protein |
| Product Code: | RPPB3768 |
| Size: | 5µg |
| Species: | Human |
| Target: | JDP2 |
| Synonyms: | Jun dimerization protein 2, JDP2, JUNDM2, Progesterone Receptor Co-Activator. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | JDP2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 1mM DTT, 1mM EDTA and 250mM imidazole. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMMPGQI PDPSVTTGSL PGLGPLTGLP SSALTVEELK YADIRNLGAM IAPLHFLEVK LGKRPQPVKS ELDEEEERRK RRREKNKVAA ARCRNKKKER TEFLQRESER LELMNAELKT QIEELKQERQ QLILMLNRHR PTCIVRTDSV KTPESEGNPL LEQLEKK |
Jun dimerization protein 2 (JDP2) is a component of the AP-1 transcription factor which inhibits transactivation mediated by the Jun family of proteins. JDP2 is involved in various transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. In addition, JDP2 can act as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. JDP2 controls transcription via direct regulation of the modification of histones and the assembly of chromatin.
JDP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 187 amino acids (1-163 a.a) and having a molecular mass of 21.2kDa.JDP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | JDP2: a transcriptional coregulator that may play a role in progesterone receptor signaling. a JDP-2 lacks an intrinsic activation domain and interacts directly with other coactivators including CBP and pCAF. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: nucleus Molecular Function:chromatin binding; protein binding; protein heterodimerization activity Biological Process: negative regulation of fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; transcription, DNA-dependent |
| UniProt Code: | Q8WYK2 |
| NCBI GenInfo Identifier: | 205277421 |
| NCBI Gene ID: | 122953 |
| NCBI Accession: | NP_001128521.1 |
| UniProt Secondary Accession: | Q8WYK2,O95430, Q9UIE4, J3KN58, |
| UniProt Related Accession: | Q8WYK2 |
| Molecular Weight: | Calculated MW: 19Observed MW: 22 |
| NCBI Full Name: | jun dimerization protein 2 isoform b |
| NCBI Synonym Full Names: | Jun dimerization protein 2 |
| NCBI Official Symbol: | JDP2�� |
| NCBI Official Synonym Symbols: | JUNDM2�� |
| NCBI Protein Information: | jun dimerization protein 2 |
| UniProt Protein Name: | Jun dimerization protein 2 |
| Protein Family: | Jun dimerization protein |
| UniProt Gene Name: | JDP2�� |
| UniProt Entry Name: | JDP2_HUMAN |
