Human LAIR1 Recombinant Protein (RPPB3833)
- SKU:
- RPPB3833
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q6GTX8
Description
| Product Name: | Human LAIR1 Recombinant Protein |
| Product Code: | RPPB3833 |
| Size: | 20µg |
| Species: | Human |
| Target: | LAIR1 |
| Synonyms: | Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305 antigen, LAIR1, CD305. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein (1mg/ml) contains 20mM Tris-HCl (pH7.5) 50mM NaCl and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPSESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG |
LAIR1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region. LAIR1 is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
LAIR1 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 105 and having a molecular mass of 11.5 kDa. The extracellular domain of LAIR-1 (22-125aa) was overexpressed in E.coli, and purified by using conventional chromatography techniques.
| UniProt Protein Function: | LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: regulation of immune response |
| NCBI Summary: | The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Code: | Q6GTX8 |
| NCBI GenInfo Identifier: | 74736490 |
| NCBI Gene ID: | 3903 |
| NCBI Accession: | Q6GTX8.1 |
| UniProt Related Accession: | Q6GTX8 |
| Molecular Weight: | 23,049 Da |
| NCBI Full Name: | Leukocyte-associated immunoglobulin-like receptor 1 |
| NCBI Synonym Full Names: | leukocyte associated immunoglobulin like receptor 1 |
| NCBI Official Symbol: | LAIR1�� |
| NCBI Official Synonym Symbols: | CD305; LAIR-1�� |
| NCBI Protein Information: | leukocyte-associated immunoglobulin-like receptor 1 |
| UniProt Protein Name: | Leukocyte-associated immunoglobulin-like receptor 1 |
| UniProt Synonym Protein Names: | CD_antigen: CD305 |
| Protein Family: | Leukocyte-associated immunoglobulin-like receptor |
| UniProt Gene Name: | LAIR1�� |
| UniProt Entry Name: | LAIR1_HUMAN |
