Human LAIR2 Recombinant Protein (RPPB5900)
- SKU:
- RPPB5900
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q6ISS4
Description
| Product Name: | Human LAIR2 Recombinant Protein |
| Product Code: | RPPB5900 |
| Size: | 20µg |
| Species: | Human |
| Target: | LAIR2 |
| Synonyms: | Leukocyte-associated immunoglobulin-like receptor 2, LAIR-2, CD306, LAIR2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | LAIR2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMQEGAL PRPSISAEPG TVISPGSHVT FMCRGPVGVQ TFRLEREDRA KYKDSYNVFR LGPSESEARF HIDSVSEGNA GLYRCLYYKP PGWSEHSDFL ELLVKGTVPG TEASGFDAP |
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) is a secreted, 131 amino acids protein which contains one IglikeC2 type domain, rendering it a member of the Ig superfamily. Even though one is secreted and one is membrane bound, the 2 LAIR proteins are assumed to have evolved from a common gene ancestor and seem to share similar adhesion profiles, suggesting that LAIR2 may compete with LAIR1 for ligand binding. LAIR2 was discovered by its similarity to LAIR1, which is an inhibitory receptor present on mononuclear leukocytes. The LAIR2 gene maps to a region of 19q13.4, dubbed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of the LAIR2 protein is unknown, though it is assumed to be secreted and may help modulate mucosal tolerance.
LAIR2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 139 amino acids (22-135 a.a) and having a molecular mass of 15.2kDa.LAIR2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LAIR-2: 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: extracellular region |
| NCBI Summary: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| UniProt Code: | Q6ISS4 |
| NCBI GenInfo Identifier: | 10947101 |
| NCBI Gene ID: | 3904 |
| NCBI Accession: | NP_002279.2 |
| UniProt Secondary Accession: | Q6ISS4,Q6PEZ4, |
| UniProt Related Accession: | Q6ISS4 |
| Molecular Weight: | |
| NCBI Full Name: | leukocyte-associated immunoglobulin-like receptor 2 isoform a |
| NCBI Synonym Full Names: | leukocyte-associated immunoglobulin-like receptor 2 |
| NCBI Official Symbol: | LAIR2�� |
| NCBI Official Synonym Symbols: | CD306; MGC71634�� |
| NCBI Protein Information: | leukocyte-associated immunoglobulin-like receptor 2; LAIR-2; OTTHUMP00000068389; OTTHUMP00000068390; leukocyte-associated Ig-like receptor 2; leukocyte-associated Ig-like receptor-2 |
| UniProt Protein Name: | Leukocyte-associated immunoglobulin-like receptor 2 |
| Protein Family: | Leukocyte-associated immunoglobulin-like receptor |
| UniProt Gene Name: | |
| UniProt Entry Name: | LAIR2_HUMAN |
