Human LIPG Recombinant Protein (RPPB1906)
- SKU:
- RPPB1906
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y5X9
- Research Area:
- Enzymes
Description
| Product Name: | Human LIPG Recombinant Protein |
| Product Code: | RPPB1906 |
| Size: | 20µg |
| Species: | Human |
| Target: | LIPG |
| Synonyms: | LIPG, Lipase Endothelial, EDL, EL, Endothelial Cell-Derived Lipase, EC 3.1.1.3, PRO719, Endothelial Lipase, Lipoprotein Lipase H, EC 3.1.1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The LIPG solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSPVPFGP EGRLEDKLHK PKATQTEVKP SVRFNLRTSK DPEHEGCYLS VGHSQPLEDC SFNMTAKTFF IIHGWTMSGI FENWLHKLVS ALHTREKDAN VVVVDWLPLA HQLYTDAVNN TRVVGHSIAR MLDWLQEKDD FSLGNVHLIG YSLGAHVAGY AGNFVKGTVG RITGLDPAGP MFEGADIHKR LSPDDADFVD VLHTYTRSFG LSIGIQMPVG HIDIYPNGGD FQPGCGLNDV LGSIAYGTIT EVVKCEHERA VHLFVDSLVN QDKPSFAFQC TDSNRFKKGI CLSCRKNRCN SIGYNAKKMR NKRNSKMYLK TRA |
Lipase Endothelial (LIPG) has extensive phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. The LIPG protein is considered a member of the TG lipase family through its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. In addition, the LIPG has triglyceride lipase activities. LIPG hydrolyzes HDLs more efficiently than other lipoproteins.
LIPG Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (21-340) and having a molecular mass of 38kDa.LIPG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LIPG: Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - glycerolipid; Phospholipase; Secreted; EC 3.1.1.3; Secreted, signal peptide Chromosomal Location of Human Ortholog: 18q21.1 Cellular Component: Golgi apparatus; extracellular space; cell surface; early endosome Molecular Function:heparin binding; lipoprotein lipase activity; phospholipase A1 activity; phospholipase activity Biological Process: cell proliferation; cholesterol homeostasis; reverse cholesterol transport; phospholipid catabolic process; regulation of lipoprotein metabolic process; lipid metabolic process; positive regulation of cholesterol transport; response to nutrient; phospholipid homeostasis |
| NCBI Summary: | The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5X9 |
| NCBI GenInfo Identifier: | 22001808 |
| NCBI Gene ID: | 9388 |
| NCBI Accession: | Q9Y5X9.1 |
| UniProt Secondary Accession: | Q9Y5X9,Q6P9C8, Q6UW82, B0LPG6, |
| UniProt Related Accession: | Q9Y5X9 |
| Molecular Weight: | 500 |
| NCBI Full Name: | Endothelial lipase |
| NCBI Synonym Full Names: | lipase, endothelial |
| NCBI Official Symbol: | LIPG�� |
| NCBI Official Synonym Symbols: | EL; EDL; PRO719�� |
| NCBI Protein Information: | endothelial lipase; lipoprotein lipase H; endothelial cell-derived lipase |
| UniProt Protein Name: | Endothelial lipase |
| UniProt Synonym Protein Names: | Endothelial cell-derived lipase; EDL; EL |
| Protein Family: | Endothelial lipase |
| UniProt Gene Name: | LIPG�� |
| UniProt Entry Name: | LIPE_HUMAN |
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