Human LTA4H Recombinant Protein (RPPB1913)
- SKU:
- RPPB1913
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P09960
- Research Area:
- Enzymes
Description
| Product Name: | Human LTA4H Recombinant Protein |
| Product Code: | RPPB1913 |
| Size: | 10µg |
| Species: | Human |
| Target: | LTA4H |
| Synonyms: | Leukotriene A-4 hydrolase isoform1, LTA-4 hydrolase, LeukotrieneA(4) hydrolase, LTA4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | LTA4H protein solution (0.25mg/ml) in Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPEIVDT CSLASPASVC RTKHLHLRCS VDFTRRTLTG TAALTVQSQEDNLRSLVLDT KDLTIEKVVI NGQEVKYALG ERQSYKGSPM EISLPIALSK NQEIVIEISF ETSPKSSALQWLTPEQTSGK EHPYLFSQCQ AIHCRAILPC QDTPSVKLTY TAEVSVPKEL VALMSAIRDG ETPDPEDPSRKIYKFIQKVP IPCYLIALVV GALESRQIGP RTLVWSEKEQ VEKSAYEFSE TESMLKIAED LGGPYVWGQYDLLVLPPSFP YGGMENPCLT FVTPTLLAGD KSLSNVIAHE ISHSWTGNLV TNKTWDHFWL NEGHTVYLERHICGRLFGEK FRHFNALGGW GELQNSVKTF GETHPFTKLV VDLTDIDPDV AYSSVPYEKG FALLFYLEQL LGGPEIFLGFLKAYVEKFSY KSITTDDWKD FLYSYFKDKV DVLNQVDWNA WLYSPGLPPI KPNYDMTLTN ACIALSQRWITAKEDDLNSF NATDLKDLSS HQLNEFLAQT LQRAPLPLGH IKRMQEVYNF NAINNSEIRF RWLRLCIQSKWEDAIPLALK MATEQGRMKF TRPLFKDLAA FDKSHDQAVR TYQEHKASMH PVTAMLVGKD LKVD |
Leukotriene A-4 hydrolase (LTA4H) is a bifunctional enzyme that converts leukotriene A4 to leukotriene B4 and functions as an aminopeptidase. The LTA4H enzyme is a member of the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). LTA4H participates in arachidonic acid metabolism.
LTA4H Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 634 amino acids (1-611 a.a) and having a molecular mass of 71.7kDa.LTA4H is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LTA4H: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Belongs to the peptidase M1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.3.2.6; Hydrolase; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 12q22 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function:peptidase activity; leukotriene-A4 hydrolase activity; metallopeptidase activity; zinc ion binding; epoxide hydrolase activity; aminopeptidase activity Biological Process: leukotriene biosynthetic process; peptide catabolic process; arachidonic acid metabolic process; leukotriene metabolic process; proteolysis; inflammatory response |
| NCBI Summary: | The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P09960 |
| NCBI GenInfo Identifier: | 126353 |
| NCBI Gene ID: | 4048 |
| NCBI Accession: | P09960.2 |
| UniProt Related Accession: | P09960 |
| Molecular Weight: | ~ 69kDa |
| NCBI Full Name: | Leukotriene A-4 hydrolase |
| NCBI Synonym Full Names: | leukotriene A4 hydrolase |
| NCBI Official Symbol: | LTA4H�� |
| NCBI Protein Information: | leukotriene A-4 hydrolase |
| UniProt Protein Name: | Leukotriene A-4 hydrolase |
| UniProt Synonym Protein Names: | Leukotriene A(4) hydrolase |
| Protein Family: | Leukotriene A-4 hydrolase |
| UniProt Gene Name: | LTA4H�� |
| UniProt Entry Name: | LKHA4_HUMAN |
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